Lab logo

Laboratory of
Ocular Biomechanics

University of Pittsburgh

Copyright Notice: The publishers hold the copyright of these articles. The PDFs are provided here to ensure rapid dissemination of scholarly work. It is understood that you will use them only in a manner consistent with the fair-use provisions of the relevant copyright laws. You may not distribute them or use them for any commercial enterprise.

bioRxiv Notice: Papers in biorXiv have not completed peer-review yet.

Publications

See publications of Dr. Sigal in PubMed, Google Scholar and Research Gate.

image

Navigate Publications

Sort: Year Title 1st Author Journal

Filter: Show All Year Author Journal Publication Type Technique

In-press 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 earlier Akagi Alman Amini Austin Baskaran Bellezza Beltran Bernick Bilonick Bingrui Brazile Brown Burgoyne Cardini Conner Chan Chau Chen Chua Demirel Downs Downling Drexler Dupps Eilaghi Ellisman Ethier Ferguson Fisher Flanagan Folio Folz Fortune Francis Frutigger Fujimoto Garzón Girard Gogola Gomez Gong Grimm Grube Grulkowski Grytz Hammer Hardisty Hardin He Hewitt Ho Hornegger Hu Hua Ishikawa Jakobs Jan Jin Kagemann Kainerstorfer Kim Kostanyan Kraus Lam Lathrop Leung Lewis Liang Ling Liu Lu Lucy Loewen-RT Loewen-NA Mackey Masland Mentley Meschke Michaelian Minckler Mitchell Moed Morrison Nadler Nam Nelson Nevins Norman Overby Pant Patel Portnoy Po-Yi Quigley Rausch Reid Reynaud Reyes-Nava Roberts Rodriguez-Hernández Roy Ruberti Ruddle Ruesch Sandrian Sanfilippo Scarcelli Schuman Schmitt Sharma Sibony Sigal Sivak Sled Smith Sofroniew Squires Steele Stowell Strouthidis Tamm Tertinegg Thompson Tran Tse Tyler-Kabara Van der Merwe Voorhees Wallace Wang Waxman Wei Whyne Williams Wiggs Wollstein Wu-EX Wu-S Xu Yang-B Yang-H Yang-X Yu Yun Zhu Acta Biomaterialia Annals of Biomedical Engineering Biomechanics and Modeling in Mechanobiology Biomedical Optics Express British Journal of Ophthalmology Current Eye Research Computational Fluid and Solid Mechanics Experimental Eye Research IEEE Transactions on Medical Imaging Investigative Ophthalmology & Visual Science Journal of Biomechanics Journal of Biomedical Optics Journal of Biophotonics Journal of Bone and Joint Surgery Journal of Medical Robotics Research Journal for Modeling in Ophthalmology Journal of Visualized Experiments Mechanics of Materials Ophthalmology The Ocular Surface PLOS ONE Physics Review Scientific Reports SPIE Proceedings Technology and Health Care Article Review Book Chapter Letter to the Editor Peer-Reviewed Proceedings Optical Coherence Tomography Nonlinear Microscopy Magnetic Resonance Imaging Polarized Light Microscopy Histology Modeling NIRS Review Other
loading

loading publications

image
  • Collagen microarchitecture from polarized light imaging: A biomechanics perspective
  • Bohlmann Kunz, M., Lee, P. Y., Latour, G., Yang, B., Schanne-Klein, M. C., Kurokawa, K., & Sigal, I. A.
  • Accepted by Journal of Biomedical Optics December 2025.
image
  • Collagen microarchitecture from polarized light imaging: A biomechanics perspective
  • Bohlmann Kunz, M., Lee, P. Y., Latour, G., Yang, B., Schanne-Klein, M. C., Kurokawa, K., & Sigal, I. A.
  • Accepted by Journal of Biomedical Optics December 2025.
image
  • Capturing sclera anisotropy using direct collagen fiber models; Linking microstructure to macroscopic mechanical properties
  • F Ji *, X He *, MR Islam, F Sebastian, H Schilpp, B Wang, Y Hua, R Amini and IA Sigal * Authors contributed equally to the manuscript
  • Accepted by Biomechanics and Modeling in Mechanobiology on 23 November 2025. Preprint posted to biorxiv on September 2024.
image
  • Capturing sclera anisotropy using direct collagen fiber models; Linking microstructure to macroscopic mechanical properties
  • F Ji *, X He *, MR Islam, F Sebastian, H Schilpp, B Wang, Y Hua, R Amini and IA Sigal * Authors contributed equally to the manuscript
  • Accepted by Biomechanics and Modeling in Mechanobiology on 23 November 2025. Preprint posted to biorxiv on September 2024.
image
  • Lamina cribrosa shape in non-human primates is different from that of humans
  • Miriam Bohlmann Kunz, Ziyi Zhu, Susannah Waxman, Bo Wang, Jacob Wallace, Samantha E. Schmitt, Hiroshi Ishikawa, Joel S. Schuman, Matthew A. Smith, Gadi Wollstein, Ian A. Sigal
  • Experimental eye research, 261, 110696. https://doi.org/10.1016/j.exer.2025.110696
image
  • Lamina cribrosa shape in non-human primates is different from that of humans
  • Miriam Bohlmann Kunz, Ziyi Zhu, Susannah Waxman, Bo Wang, Jacob Wallace, Samantha E. Schmitt, Hiroshi Ishikawa, Joel S. Schuman, Matthew A. Smith, Gadi Wollstein, Ian A. Sigal
  • Experimental eye research, 261, 110696. https://doi.org/10.1016/j.exer.2025.110696
image
  • Selective Deletion of NBCe1 in Reactive Astrocytes Attenuates Ischemic Stroke Brain Damage
  • Capuk O, Berthold E, Kaliyappan K, Avunoori M, Muduganti R, Krishna S, Metwally S, McFarland M, Song S, Fiesler V, Fischer S, Foley LM, Hitchens TK, Waxman S, Sigal IA, Theparambil SM, Begum G.
  • Glia, 73(12), 2386–2406. https://doi.org/10.1002/glia.70075
image
  • Selective Deletion of NBCe1 in Reactive Astrocytes Attenuates Ischemic Stroke Brain Damage
  • Capuk O, Berthold E, Kaliyappan K, Avunoori M, Muduganti R, Krishna S, Metwally S, McFarland M, Song S, Fiesler V, Fischer S, Foley LM, Hitchens TK, Waxman S, Sigal IA, Theparambil SM, Begum G.
  • Glia, 73(12), 2386–2406. https://doi.org/10.1002/glia.70075
image
  • Multiscale analysis of equatorial sclera anisotropy: Revealing discrepancies in fiber orientation and mechanical properties
  • Li R, Hua Y, Zhang F, Qian X, Gong C, Wan X, Waxman S, Zeng Y, Che Z, Zhang J, Jin W, Humayun MS, Chen Z, Sigal IA, Zhou Q.
  • Science advances, 11(28), eadp8631. https://doi.org/10.1126/sciadv.adp8631
image
  • Multiscale analysis of equatorial sclera anisotropy: Revealing discrepancies in fiber orientation and mechanical properties
  • Li R, Hua Y, Zhang F, Qian X, Gong C, Wan X, Waxman S, Zeng Y, Che Z, Zhang J, Jin W, Humayun MS, Chen Z, Sigal IA, Zhou Q.
  • Science advances, 11(28), eadp8631. https://doi.org/10.1126/sciadv.adp8631
image
  • Pericytes in the optic nerve head
  • Waxman S, Villafranca-Baughman D, Phillippi J, Jakobs TC, Alarcon-Martinez L, Di Polo A, Sigal IA
  • Prog Retin Eye Res. 2025 May 29:101375. doi: 10.1016/j.preteyeres.2025.101375. PMID: 40449651.
image
  • Pericytes in the optic nerve head
  • Waxman S, Villafranca-Baughman D, Phillippi J, Jakobs TC, Alarcon-Martinez L, Di Polo A, Sigal IA
  • Prog Retin Eye Res. 2025 May 29:101375. doi: 10.1016/j.preteyeres.2025.101375. PMID: 40449651.
image
  • Lamina cribrosa hypoxia sensitivity to variations of anatomy and vascular factors
  • Yuankai Lu, Yi Hua, Po-Yi Lee, Andrew Theophanous, Shaharoz Tahir, Qi Tian, Ian A Sigal
  • J Biomech Eng. 2025 Aug 1;147(8):081002. doi: 10.1115/1.4068577. PMID: 40314737.
image
  • Lamina cribrosa hypoxia sensitivity to variations of anatomy and vascular factors
  • Yuankai Lu, Yi Hua, Po-Yi Lee, Andrew Theophanous, Shaharoz Tahir, Qi Tian, Ian A Sigal
  • J Biomech Eng. 2025 Aug 1;147(8):081002. doi: 10.1115/1.4068577. PMID: 40314737.
  • [Video]
image
  • Impact of elevated IOP on lamina cribrosa oxygenation; A combined experimental-computational study on monkeys
  • Yuankai Lu, Yi Hua, Bingrui Wang, Fuqiang Zhong, Andrew Theophanous, Shaharoz Tahir, Po-Yi Lee, Ian A Sigal

image
  • Impact of elevated IOP on lamina cribrosa oxygenation; A combined experimental-computational study on monkeys
  • Yuankai Lu, Yi Hua, Bingrui Wang, Fuqiang Zhong, Andrew Theophanous, Shaharoz Tahir, Po-Yi Lee, Ian A Sigal
  • Ophthalmol Sci. 2025 Jan 31;5(3):100725. doi: 10.1016/j.xops.2025.100725. PMID: 40161464; PMCID: PMC11950774.
  • [ Video 1, Video 2, Video 3]
  • [ Video 4, Video 5]
image
  • Morphological comparison of astrocytes in the lamina cribrosa and glial lamina
  • Susannah Waxman, Hannah Schilpp, Ashley Linton, Tatjana C. Jakobs, Ian A. Sigal
  • Invest Ophthalmol Vis Sci. 2025 Mar 3;66(3):1. doi: 10.1167/iovs.66.3.1. PMID: 40029245; PMCID: PMC11887932..
image
  • Morphological comparison of astrocytes in the lamina cribrosa and glial lamina
  • Susannah Waxman, Hannah Schilpp, Ashley Linton, Tatjana C. Jakobs, Ian A. Sigal
  • Invest Ophthalmol Vis Sci. 2025 Mar 3;66(3):1. doi: 10.1167/iovs.66.3.1. PMID: 40029245; PMCID: PMC11887932.
image
  • Comparing continuum and direct fiber models of soft tissues. An ocular biomechanics example reveals that continuum models may artificially disrupt the strains at both the tissue and fiber levels
  • Xuehuan He, Mohammad R. Islam, Fengting Ji, Bingrui Wang, Ian A. Sigal
image
  • Comparing continuum and direct fiber models of soft tissues. An ocular biomechanics example reveals that continuum models may artificially disrupt the strains at both the tissue and fiber levels
  • Xuehuan He, Mohammad R. Islam, Fengting Ji, Bingrui Wang, Ian A. Sigal
  • Acta Biomater. 2024 Dec;190:317-328. doi: 10.1016/j.actbio.2024.10.019. PMID: 39424020.
image
  • Proposing a methodology for axon-centric analysis of IOP-induced mechanical insult
  • Manik Bansal, Bingrui Wang, Susannah Waxman, Fuqiang Zhong, Yi Hua, Yuankai Lu, Juan Reynaud, Brad Fortune, Ian A. Sigal.
  • Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):1. doi: 10.1167/iovs.65.13.1. PMID: 39495185; PMCID: PMC11539975.
image
  • Proposing a methodology for axon-centric analysis of IOP-induced mechanical insult
  • Manik Bansal, Bingrui Wang, Susannah Waxman, Fuqiang Zhong, Yi Hua, Yuankai Lu, Juan Reynaud, Brad Fortune, Ian A. Sigal.
  • Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):1. doi: 10.1167/iovs.65.13.1. PMID: 39495185; PMCID: PMC11539975.
image
  • Lamina Cribrosa Insertions Into the Sclera Are Sparser, Narrower, and More Slanted in the Anterior Lamina
  • Ji F, Islam MR, Wang B, Hua Y, Sigal IA.
  • Invest Ophthalmol Vis Sci. 2024;65(4):35. doi:10.1167/iovs.65.4.35
image
  • Lamina Cribrosa Insertions Into the Sclera Are Sparser, Narrower, and More Slanted in the Anterior Lamina
  • Ji F, Islam MR, Wang B, Hua Y, Sigal IA.
  • Invest Ophthalmol Vis Sci. 2024;65(4):35. doi:10.1167/iovs.65.4.35
image
  • The Robust Lamina Cribrosa Vasculature: Perfusion and Oxygenation Under Elevated Intraocular Pressure
  • Yuankai Lu; Yi Hua; Bingrui Wang; Fuqiang Zhong; Andrew Theophanous; Shaharoz Tahir; Po-Yi Lee; Ian A. Sigal
  • Invest Ophthalmol Vis Sci. 2024;65(5):1. doi:10.1167/iovs.65.5.1
image
  • The Robust Lamina Cribrosa Vasculature: Perfusion and Oxygenation Under Elevated Intraocular Pressure
  • Yuankai Lu; Yi Hua; Bingrui Wang; Fuqiang Zhong; Andrew Theophanous; Shaharoz Tahir; Po-Yi Lee; Ian A. Sigal
  • Invest Ophthalmol Vis Sci. 2024;65(5):1. doi:10.1167/iovs.65.5.1
image
  • Fibrous finite element modeling of the optic nerve head region
  • MR Islam, F Ji, M Bansal, Y Hua and IA Sigal
  • Acta Biomaterialia 2024;175:123-137. doi:10.1016/j.actbio.2023.12.034.
image
  • Fibrous finite element modeling of the optic nerve head region
  • MR Islam, F Ji, M Bansal, Y Hua and IA Sigal
  • Acta Biomaterialia 2024;175:123-137. doi:10.1016/j.actbio.2023.12.034.
image
  • Direct measurements of collagen fiber recruitment in the posterior pole of the eye
  • PY Lee, G Fryc, J Gnalian, Y Hua, S Waxman, F Zhong, B Yang and IA Sigal
  • Acta Biomaterialia 2024 Jan 1:173:135-147. doi: 10.1016/j.actbio.2023.11.013
image
  • Direct measurements of collagen fiber recruitment in the posterior pole of the eye
  • PY Lee, G Fryc, J Gnalian, Y Hua, S Waxman, F Zhong, B Yang and IA Sigal
  • Acta Biomaterialia 2024 Jan 1:173:135-147. doi: 10.1016/j.actbio.2023.11.013
image
  • 2D or not 2D? Mapping the in-depth inclination of the collagen fibers of the corneoscleral shell
  • F Ji, M Quinn, B Wang, PY Lee, and IA Sigal
  • Experimental Eye Research 2023 Dec:237:109701. doi: 10.1016/j.exer.2023.109701
image
  • 2D or not 2D? Mapping the in-depth inclination of the collagen fibers of the corneoscleral shell
  • F Ji, M Quinn, B Wang, PY Lee, and IA Sigal
  • Experimental Eye Research 2023 Dec:237:109701. doi: 10.1016/j.exer.2023.109701
image
  • A direct fiber approach to model sclera collagen architecture and biomechanics
  • F Ji, M Bansal, B Wang, Y Hua, MR Islam, F Matuschke, M Axer, and IA Sigal
  • Experimental Eye Research. 2023 Jul:232:109510. doi: 10.1016/j.exer.2023.109510
image
  • A direct fiber approach to model sclera collagen architecture and biomechanics
  • F Ji, M Bansal, B Wang, Y Hua, MR Islam, F Matuschke, M Axer, and IA Sigal
  • Experimental Eye Research. 2023 Jul:232:109510. doi: 10.1016/j.exer.2023.109510
image
  • Predatory Bacteria can Reduce Pseudomonas aeruginosa Induced Corneal Perforation and Proliferation in a Rabbit Keratitis Model  
  • EG Romanowski, NA Stella, BL Brazile, KL Lathrop, JM Franks, IA Sigal, T Kim, M Elsayed, DE Kadouri and RMQ Shanks
  • Ocul Surf. 2023 Apr:28:254-261. doi: 10.1016/j.jtos.2023.05.002
image
  • Predatory Bacteria can Reduce Pseudomonas aeruginosa Induced Corneal Perforation and Proliferation in a Rabbit Keratitis Model  
  • EG Romanowski, NA Stella, BL Brazile, KL Lathrop, JM Franks, IA Sigal, T Kim, M Elsayed, DE Kadouri and RMQ Shanks
  • Ocul Surf. 2023 Apr:28:254-261. doi: 10.1016/j.jtos.2023.05.002
image
  • Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues  
  • PY Lee, H Schilpp, N Naylor, SC Watkins, B Yang, and IA Sigal
  • Optics and Lasers in Engineering, July 2023, PMID: 36778384 doi: j.optlaseng.2023.107594
image
  • Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues  
  • PY Lee, H Schilpp, N Naylor, SC Watkins, B Yang, and IA Sigal
  • Optics and Lasers in Engineering, July 2023, PMID: 36778384 doi: j.optlaseng.2023.107594
image
  • Individual astrocyte morphology in the collagenous lamina cribrosa revealed by multicolor DiOlistic labeling
  • S Waxman, M Quinn, C Donahue, LD Falo Jr, TC Jakobs, D Sun, and IA Sigal
  • Experimental Eye Research, May 2023, PMID: 36965593 doi:2022.12.24.520184
image
  • Individual astrocyte morphology in the collagenous lamina cribrosa revealed by multicolor DiOlistic labeling
  • S Waxman, M Quinn, C Donahue, LD Falo Jr, TC Jakobs, D Sun, and IA Sigal
  • Experimental Eye Research, May 2023, PMID: 36965593 doi:2022.12.24.520184
image
  • Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell
  • TY Foong, Y Hua, R Amini, and IA Sigal
  • Experimental Eye Research, May 2023, PMID: 36935071 doi:j.exer.2023.109446.
image
  • Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell
  • TY Foong, Y Hua, R Amini, and IA Sigal
  • Experimental Eye Research, May 2023, PMID: 36935071 doi:j.exer.2023.109446.
image
  • Stretch-induced uncrimping of equatorial sclera collagen bundle
  • NJ Jan, PY Lee, J Wallace, M Iasella, A Gogola, B Wang and IA Sigal
  • ASME Journal of Biomechanical Engineering, Nov 2022, 2022.09.13.507860
image
  • Stretch-induced uncrimping of equatorial sclera collagen bundle
  • NJ Jan, PY Lee, J Wallace, M Iasella, A Gogola, B Wang and IA Sigal
  • ASME Journal of Biomechanical Engineering, Nov 2022, 2022.09.13.507860
image
  • Comparing acute IOP-induced lamina cribrosa deformations pre-mortem and post-mortem
  • J Wei, Y Hua, B Yang, B Wang, SE Schmitt, B Wang, KA Lucy, H Ishikawa, JS Schuman, MA Smith, G Wollstein, IA Sigal
  • Translational Vision Science & Technology, Oct 2022, 2022.09.18.508448
image
  • Comparing acute IOP-induced lamina cribrosa deformations pre-mortem and post-mortem
  • J Wei, Y Hua, B Yang, B Wang, SE Schmitt, B Wang, KA Lucy, H Ishikawa, JS Schuman, MA Smith, G Wollstein, IA Sigal
  • Translational Vision Science & Technology, Oct 2022, 2022.09.18.508448
image
  • Evidence of an Annexin A4 mediated plasma membrane repair response to biomechanical strain associated with glaucoma pathogenesis
  • N Vicic, X Guo, D Chan, JG Flanagan, IA Sigal, JM Sivak
image
  • Evidence of an Annexin A4 mediated plasma membrane repair response to biomechanical strain associated with glaucoma pathogenesis
  • N Vicic, X Guo, D Chan, JG Flanagan, IA Sigal, JM Sivak
  • Journal of Cellular Physiology, 2022 Sep;237(9):3687-3702, Epub July 21. doi: 10.1002/jcp.30834. PMID: 35862065.
image
  • Eye-specific 3D modeling of factors influencing oxygen concentration in the lamina cribrosa
  • Y Hua, Y Lu, J Walker, PY Lee, Q Tian, H McDonald, P Pallares, F Ji, BL Brazile, B Yang, AP Vorhees, IA Sigal
  • [Video 1, Video 2]
image
  • Eye-specific 3D modeling of factors influencing oxygen concentration in the lamina cribrosa
  • Y Hua, Y Lu, J Walker, PY Lee, Q Tian, H McDonald, P Pallares, F Ji, BL Brazile, B Yang, AP Vorhees, IA Sigal
  • Experimental Eye Research, 2022;220:109105. July 2022. doi: 10.1016/j.exer.2022.109105. PMID: 35568202.
  • [Video 1, Video 2]
image
  • A high-accuracy and high-efficiency digital volume correlation method to characterize in-vivo optic nerve head biomechanics from optical coherence tomography
  • F Zhong, B Wang, J Wei, Y Hua, B Wang, J Reynaud, B Fortune, IA Sigal
image
  • A high-accuracy and high-efficiency digital volume correlation method to characterize in-vivo optic nerve head biomechanics from optical coherence tomography
  • F Zhong, B Wang, J Wei, Y Hua, B Wang, J Reynaud, B Fortune, IA Sigal
  • Acta Biomaterialia, 2022;143:72-86. April 2022, doi:10.1016/j.actbio.2022.02.021. PMID 35196556.
image
  • A workflow for 3D reconstruction and quantification of the monkey optic nerve head vascular network
  • PY Lee, Y Hua, BL Brazile, B Yang, L Wang, IA Sigal
  • ASME Journal of Biomechanical Engineering, 2022;144(6):061006. June 2022, doi:10.1115/1.4054056
image
  • A workflow for 3D reconstruction and quantification of the monkey optic nerve head vascular network
  • PY Lee, Y Hua, BL Brazile, B Yang, L Wang, IA Sigal
  • ASME Journal of Biomechanical Engineering, 2022;144(6):061006. June 2022, doi:10.1115/1.4054056
image
  • Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy
  • PY Lee, B Yang, Y Hua, S Waxman, Z Ziyi, F Ji, IA Sigal
  • Experimental eye research, 217, 109867, April 2022.
image
  • Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy
  • PY Lee, B Yang, Y Hua, S Waxman, Z Ziyi, F Ji, IA Sigal
  • Experimental eye research, 217, 109867, April 2022.
image
  • Lamina cribrosa vessel and collagen beam networks are distinct
  • S Waxman ,BL Brazile, B Yang, PY Lee, Y Hua, AL Gogola, P Lam, AP Voorhees, III JF Rizzo, TC Jakobs, IA Sigal
  • Experimental eye research, 215, 108916, December 2021.
image
  • Lamina cribrosa vessel and collagen beam networks are distinct
  • S Waxman, BL Brazile, B Yang, PY Lee, Y Hua, AL Gogola, P Lam, AP Voorhees, III JF Rizzo, TC Jakobs, IA Sigal
  • Experimental eye research, 215, 108916, December 2021.
image
  • Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo
  • Z Zhu, S Waxman, B Wang, J Wallace, SE Schmitt, E Tyler-Kabara, H Ishikawa, JS Schuman, MA Smith, G Wollstein, IA Sigal
  • Experimental eye research, 213, 108809, December 2021.
image
  • Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo
  • Z Zhu, S Waxman, B Wang, J Wallace, SE Schmitt, E Tyler-Kabara, H Ishikawa, JS Schuman, MA Smith, G Wollstein, IA Sigal
  • Experimental eye research, 213, 108809, December 2021.
image
  • Instant polarized light microscopy for imaging collagen microarchitecture and dynamics
  • B Yang, PY Lee, Y Hua, B Brazile, S Waxman, F Ji, Z Zhu and IA Sigal
  • Journal of Biophotonics, 14(2), e202000326, February 2021.
image
  • Instant polarized light microscopy for imaging collagen microarchitecture and dynamics
  • B Yang, PY Lee, Y Hua, B Brazile, S Waxman, F Ji, Z Zhu and IA Sigal
  • Journal of Biophotonics, 14(2), e202000326, February 2021.
image
  • So-called lamina cribrosa defects may mitigate IOP-induced neural tissue insult
  • A*P Voorhees, *Y Hua, BL Brazile, BR Wang, S Waxman, JS Schuman and IA Sigal
  • Investigative Ophthalmology and Visual Science, 61(15), November 2020.
  • (* Authors contributed equally to this manuscript)
image
  • So-called lamina cribrosa defects may mitigate IOP-induced neural tissue insult
  • *AP Voorhees, *Y Hua, BL Brazile, B Wang, S Waxman, JS Schuman and IA Sigal
  • Investigative Ophthalmology and Visual Science, 61(15), November 2020.
  • (* Authors contributed equally to this manuscript)
image
  • Lamina cribrosa capillaries straighten as intraocular pressure increases
  • BL Brazile, B Yang, S Waxman, P Lam, AP Voorhees, Y Hua, RT Loewen, NA Loewen, JF Rizzo, T Jakobs and IA Sigal
  • Investigative Ophthalmology and Visual Science, 61(2), October 2020.
image
  • Lamina cribrosa capillaries straighten as intraocular pressure increases
  • BL Brazile, B Yang, S Waxman, P Lam, AP Voorhees, Y Hua, RT Loewen, NA Loewen, JF Rizzo, T Jakobs and IA Sigal
  • Investigative Ophthalmology and Visual Science, 61(2), October 2020.
image
  • Role of radially aligned scleral collagen fibers in optic nerve head biomechanics
  • Y Hua, AP Voorhees, NJ Jan, BR Wang, S Waxman, JS Schuman and IA Sigal
  • Experimental eye research, 199, 108188, October 2020.
image
  • Role of radially aligned scleral collagen fibers in optic nerve head biomechanics
  • Y Hua, AP Voorhees, NJ Jan, BR Wang, S Waxman, JS Schuman and IA Sigal
  • Experimental eye research, 199, 108188, October 2020.
image
  • Collagen fiber interweaving is central to sclera stiffness
  • BR Wang, Y Hua, BL Brazile, B Yang and IA Sigal
  • Acta Biomaterialia, 113, 429-437, September 2020.
image
  • Collagen fiber interweaving is central to sclera stiffness
  • BR Wang, Y Hua, BL Brazile, B Yang and IA Sigal
  • Acta Biomaterialia, 113, 429-437, September 2020.
image
  • Connective tissue remodeling in myopia and its potential role in increasing risk of glaucoma
  • R Grytz, H Yang, Y Hua, BC Samuels, IA Sigal
  • Current Opinion in Biomedical Engineering, 15, 40-50, September 2020.
image
  • Connective tissue remodeling in myopia and its potential role in increasing risk of glaucoma
  • R Grytz, H Yang, Y Hua, BC Samuels, IA Sigal
  • Current Opinion in Biomedical Engineering, 15, 40-50, September 2020.
image
  • Effect of iStent Trabecular Micro-Bypass device on outflow system morphology
  • N Hess, N Mesiwala, C Marando, RA Bilonick, LK Seibold, JS Schuman, G Wollstein, H Ishikawa, IA Sigal, I Conner, C Jonescu-Cuypers
  • Modeling and Artificial Intelligence in Ophthalmology, 2(4), 44-54, June 2020.
image
  • Effect of iStent Trabecular Micro-Bypass device on outflow system morphology
  • N Hess, N Mesiwala, C Marando, RA Bilonick, LK Seibold, JS Schuman, G Wollstein, H Ishikawa, IA Sigal, I Conner, C Jonescu-Cuypers
  • Modeling and Artificial Intelligence in Ophthalmology, 2(4), 44-54, June 2020.
image
  • Test-retest reproducibility of atomic force microscopy measurements of human trabecular meshwork stiffness
  • L Kagemann, J Candiello, G Wollstein, H Ishikawa, RA Bilonick, IA Sigal, C Jonescu-Cuypers, PN Kumta, JS Schuman
  • Modeling and Artificial Intelligence in Ophthalmology, 2(4), 34-43, June 2020.
image
  • Test-retest reproducibility of atomic force microscopy measurements of human trabecular meshwork stiffness
  • L Kagemann, J Candiello, G Wollstein, H Ishikawa, RA Bilonick, IA Sigal, C Jonescu-Cuypers, PN Kumta, JS Schuman
  • Modeling and Artificial Intelligence in Ophthalmology, 2(4), 34-43, June 2020.
image
  • Instant polarized light microscopy for real-time wide-field visualization of collagen architecture
  • PY Lee, B Yang, Y Hua, BL Brazile, FT Ji, ZY Zhu, GA Fryc, IA Sigal
  • Proceeding of SPIE, Label-free Biomedical Imaging and Sensing (LBIS) 2020, 112510Y, February 2020.
image
  • Instant polarized light microscopy for real-time wide-field visualization of collagen architecture
  • PY Lee, B Yang, Y Hua, BL Brazile, FT Ji, ZY Zhu, GA Fryc, IA Sigal
  • Proceeding of SPIE, Label-free Biomedical Imaging and Sensing (LBIS) 2020, 112510Y, February 2020.
image
  • A mesh-free approach to incorporate complex anisotropic and heterogeneous material properties into eye-specific finite element models
  • R Grytz, K Krishnan, R Whitley, V Libertiaux, IA Sigal, CA Girkin and JC Downs
image
  • A mesh-free approach to incorporate complex anisotropic and heterogeneous material properties into eye-specific finite element models
  • R Grytz, K Krishnan, R Whitley, V Libertiaux, IA Sigal, CA Girkin and JC Downs
  • Computer Methods in Applied Mechanics and Engineering, 358, 112654, January 2020.
image
  • Scleral structure and biomechanics
  • C Boote, IA Sigal, R Grytz, Y Hua, TD Nguyen and MJA Girard
  • Progress in Retinal and Eye Research, 74, 100773, January 2020.
image
  • Scleral structure and biomechanics
  • C Boote, IA Sigal, R Grytz, Y Hua, TD Nguyen and MJA Girard
  • Progress in Retinal and Eye Research, 74, 100773, January 2020.
image
  • Structured polarized light microscopy for collagen fiber structure and orientation quantification in thick ocular tissues
  • B Yang, BL Brazile, NJ Jan, Y Hua, J Wei and IA Sigal
  • Journal of Biomedical Optics, 23(10), 106001, October 2018.
image
  • Structured polarized light microscopy for collagen fiber structure and orientation quantification in thick ocular tissues
  • B Yang, BL Brazile, NJ Jan, Y Hua, J Wei and IA Sigal
  • Journal of Biomedical Optics, 23(10), 106001, October 2018.
image
  • Radial and circumferential collagen fibers are a feature of the peripapillary sclera of human, monkey, pig, cow, goat and sheep
  • A Gogola, NJ Jan, KL Lathrop and IA Sigal
  • Investigative Ophthalmology and Visual Science, 59(12), 4763-4774, October 2018.
image
  • Radial and circumferential collagen fibers are a feature of the peripapillary sclera of human, monkey, pig, cow, goat and sheep
  • A Gogola, NJ Jan, KL Lathrop and IA Sigal
  • Investigative Ophthalmology and Visual Science, 59(12), 4763-4774, October 2018.
image
  • Thin lamina cribrosa beams have different collagen microstructure than thick beams
  • *BL Brazile, *Y Hua, NJ Jan, J Wallace, A Gogola and IA Sigal
  • Investigative Ophthalmology and Visual Science, 59(11), 4653-4661, September 2018.
  • (* Authors contributed equally to this manuscript)
image
  • Thin lamina cribrosa beams have different collagen microstructure than thick beams
  • *BL Brazile, *Y Hua, NJ Jan, J Wallace, A Gogola and IA Sigal
  • Investigative Ophthalmology and Visual Science, 59(11), 4653-4661, September 2018.
  • (* Authors contributed equally to this manuscript)
image
  • Peripapillary sclera architecture revisited: A tangential fiber model and its biomechanical implications
  • AP Voorhees, NJ Jan, Y Hua, B Yang and IA Sigal
  • Acta Biomaterialia, 79, 113-122, August 2018.
image
  • Peripapillary sclera architecture revisited: A tangential fiber model and its biomechanical implications
  • AP Voorhees, NJ Jan, Y Hua, B Yang and IA Sigal
  • Acta Biomaterialia, 79, 113-122, August 2018.
image
  • Spatial patterns and age-related changes of the collagen crimp in the human cornea and sclera
  • A Gogola, NJ Jan, BL Brazile, P Lam, KL Lathrop, K Chan, IA Sigal
  • Investigative Ophthalmology and Visual Science, 59(7), 2987-2998, June 2018.
image
  • Spatial patterns and age-related changes of the collagen crimp in the human cornea and sclera
  • A Gogola, NJ Jan, BL Brazile, P Lam, KL Lathrop, K Chan, IA Sigal
  • Investigative Ophthalmology and Visual Science, 59(7), 2987-2998, June 2018.
image
  • Tortuous pore path through the glaucomatous lamina cribrosa
  • B Wang, KA Lucy, JS Schuman, IA Sigal, RA Bilonick, C Lu, J Liu, I Grulkowski, Z Nadler, H Ishikawa, L Kagemann, JG Fujimoto and G Wollstein
  • Scientific reports, 8(1), 7281, May 2018.
image
  • Tortuous pore path through the glaucomatous lamina cribrosa
  • B Wang, KA Lucy, JS Schuman, IA Sigal, RA Bilonick, C Lu, J Liu, I Grulkowski, Z Nadler, H Ishikawa, L Kagemann, JG Fujimoto and G Wollstein
  • Scientific reports, 8(1), 7281, May 2018.
image
  • Crimp around the globe: Patterns of collagen crimp across the corneoscleral shell
  • NJ Jan, BL Brazile, D Hu, G Grube, J Wallace, A Gogola and IA Sigal
  • Experimental eye research, 172, 159-170, April 2018.
image
  • Crimp around the globe: Patterns of collagen crimp across the corneoscleral shell
  • NJ Jan, BL Brazile, D Hu, G Grube, J Wallace, A Gogola and IA Sigal
  • Experimental eye research, 172, 159-170, April 2018.
image
  • Polarized light microscopy for 3D mapping of collagen fiber architecture in ocular tissues
  • B Yang, NJ Jan, B Brazile, A Voorhees, KL Lathrop and IA Sigal
  • Journal of Biophotonics, 11(8), e201700356, August 2018.
image
  • Polarized light microscopy for 3D mapping of collagen fiber architecture in ocular tissues
  • B Yang, NJ Jan, B Brazile, A Voorhees, KL Lathrop and IA Sigal
  • Journal of Biophotonics, 11(8), e201700356, August 2018.
image
  • Structured polarized light microscopy (SPLM) for mapping collagen fiber orientation of ocular tissues
  • B Yang, B Brazile, NJ Jan, AP Voorhees and IA Sigal
  • Proceeding of SPIE, Micromirror Device Based Systems and Applications X, 105460I, February 2018.
image
  • Structured polarized light microscopy (SPLM) for mapping collagen fiber orientation of ocular tissues
  • B Yang, B Brazile, NJ Jan, AP Voorhees and IA Sigal
  • Proceeding of SPIE, Micromirror Device Based Systems and Applications X, 105460I, February 2018.
image
  • Measuring in-vivo and in-situ ex-vivo the 3D deformation of the lamina cribrosa microstructure under elevated intraocular pressure
  • J Wei, B Yang, AP Voorhees, H Tran, B Brazile, B Wang, J Schuman, MA Smith, G Wollstein and IA Sigal
  • Proceeding of SPIE, Optical Elastography and Tissue Biomechanics V, 1049611, February 2018.
image
  • Measuring in-vivo and in-situ ex-vivo the 3D deformation of the lamina cribrosa microstructure under elevated intraocular pressure
  • J Wei, B Yang, AP Voorhees, H Tran, B Brazile, B Wang, J Schuman, MA Smith, G Wollstein and IA Sigal
  • Proceeding of SPIE, Optical Elastography and Tissue Biomechanics V, 1049611, February 2018.
image
  • Seeing the hidden lamina; Effects of exsanguination on the optic nerve head
  • H Tran, J Wallace, Z Zhu, KA Lucy, AP Voorhees, SE Schmitt, RA Bilonick, JS Schuman, MA Smith, G Wollstein, and IA Sigal
  • Investigative Ophthalmology and Visual Science, 59, 2564-2575, May 2018.
image
  • Seeing the hidden lamina; Effects of exsanguination on the optic nerve head
  • H Tran, J Wallace, Z Zhu, KA Lucy, AP Voorhees, SE Schmitt, RA Bilonick, JS Schuman, MA Smith, G Wollstein, and IA Sigal
  • Investigative Ophthalmology and Visual Science, 59, 2564-2575, May 2018.
image
  • Collagen fiber recruitment: a microstructural basis for the nonlinear response of the posterior pole of the eye to increases in intraocular pressure
  • NJ Jan and IA Sigal
  • Acta Biomaterialia, 72, 295-305, May 2018.
image
  • Collagen fiber recruitment: a microstructural basis for the nonlinear response of the posterior pole of the eye to increases in intraocular pressure
  • NJ Jan and IA Sigal
  • Acta Biomaterialia, 72, 295-305, May 2018.
image
  • Gaze evoked deformations in optic nerve head drusen: repetitive shearing as a potential factor in the visual and vascular complications
  • PA Sibony, J Wei and IA Sigal
  • Ophthalmology, 125(6), 929-937, June 2018.
image
  • Gaze evoked deformations in optic nerve head drusen: repetitive shearing as a potential factor in the visual and vascular complications
  • PA Sibony, J Wei and IA Sigal
  • Ophthalmology, 125(6), 929-937, June 2018.
image
  • Cerebrospinal Fluid Pressure; Revisiting Factors Influencing Optic Nerve Head Biomechanics
  • Y Hua, AP Voorhees and IA Sigal
  • Investigative Ophthalmology and Visual Science, 59(1), 154-165, January 2018.
image
  • Cerebrospinal Fluid Pressure; Revisiting Factors Influencing Optic Nerve Head Biomechanics
  • Y Hua, AP Voorhees and IA Sigal
  • Investigative Ophthalmology and Visual Science, 59(1), 154-165, January 2018.
image
  • In-Vivo Effects of Intraocular and Intracranial Pressures on the Lamina Cribrosa Microstructure
  • *B Wang, *H Tran, MA Smith, T Kostanyan, SE Schmitt, RA Bilonick, NJ Jan, L Kagemann, EC Tyler-Kabara, H Ishikawa, JS Schuman, IA Sigal and G Wollstein
  • PLoS ONE, 12(11), e0188302, November 2017.
  • (* Authors contributed equally to this manuscript)
image
  • In-Vivo Effects of Intraocular and Intracranial Pressures on the Lamina Cribrosa Microstructure
  • *B Wang, *H Tran, MA Smith, T Kostanyan, SE Schmitt, RA Bilonick, NJ Jan, L Kagemann, EC Tyler-Kabara, H Ishikawa, JS Schuman, IA Sigal and G Wollstein
  • PLoS ONE, 12(11), e0188302, November 2017.
  • (* Authors contributed equally to this manuscript)
image
  • Lamina Cribrosa Pore Shape and Size as Predictors of Neural Tissue Mechanical Insult
  • AP Voorhees, NJ Jan, ME Austin, JG Flanagan, JM Sivak, RA Bilonick and IA Sigal
  • Investigative Ophthalmology and Visual Science, 58(12), 5336-5346, October 2017.
image
  • Lamina Cribrosa Pore Shape and Size as Predictors of Neural Tissue Mechanical Insult
  • AP Voorhees, NJ Jan, ME Austin, JG Flanagan, JM Sivak, RA Bilonick and IA Sigal
  • Investigative Ophthalmology and Visual Science, 58(12), 5336-5346, October 2017.
image
  • Formalin Fixation and Cryosectioning Cause Only Minimal Changes in Shape or Size of Ocular Tissues
  • H Tran, NJ Jan, D Hu, A Voorhees, JS Schuman, MA Smith, G Wollstein and IA Sigal
  • Scientific Reports, 7(1), 12065, September 2017.
image
  • Formalin Fixation and Cryosectioning Cause Only Minimal Changes in Shape or Size of Ocular Tissues
  • H Tran, NJ Jan, D Hu, A Voorhees, JS Schuman, MA Smith, G Wollstein and IA Sigal
  • Scientific Reports, 7(1), 12065, September 2017.
image
  • Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes
  • B Wang, KA Lucy, JS Schuman, H Ishikawa, RA Bilonick, IA Sigal, L Kagemann, C Lu, JG Fujimoto and G Wollstein
  • Scientific Reports, 7(1), 9930, August 2017.
image
  • Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes
  • B Wang, KA Lucy, JS Schuman, H Ishikawa, RA Bilonick, IA Sigal, L Kagemann, C Lu, JG Fujimoto and G Wollstein
  • Scientific Reports, 7(1), 9930, August 2017.
image
  • Effects of collagen microstructure and material properties on the deformation of the neural tissues of the lamina cribrosa
  • AP Voorhees, NJ Jan and IA Sigal
  • Acta Biomaterialia, 58, 278-290, August 2017.
image
  • Effects of collagen microstructure and material properties on the deformation of the neural tissues of the lamina cribrosa
  • AP Voorhees, NJ Jan and IA Sigal
  • Acta Biomaterialia, 58, 278-290, August 2017.
image
  • Whole-globe biomechanics using high-field MRI
  • AP Voorhees, LC Ho, NJ Jan, H Tran, Y van der Merwe, K Chan and IA Sigal
  • Experimental Eye Research, 160, 85-95, July 2017.
image
  • Whole-globe biomechanics using high-field MRI
  • AP Voorhees, LC Ho, NJ Jan, H Tran, Y van der Merwe, K Chan and IA Sigal
  • Experimental Eye Research, 160, 85-95, July 2017.
image
  • Microstructural Crimp of the Lamina Cribrosa and Peripapillary Sclera Collagen Fibers
  • NJ Jan, C Gomez, S Moed, AP Voorhees, JS Schuman, RA Bilonick and IA Sigal
  • Investigative Ophthalmology and Visual Science, 58(9), 3378-3388, July 2017.
image
  • Microstructural Crimp of the Lamina Cribrosa and Peripapillary Sclera Collagen Fibers
  • NJ Jan, C Gomez, S Moed, AP Voorhees, JS Schuman, RA Bilonick and IA Sigal
  • Investigative Ophthalmology and Visual Science, 58(9), 3378-3388, July 2017.
image
  • Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility
  • KA Lucy, B Wang, JS Schuman, RA Bilonick, Y Ling, L Kagemann, IA Sigal, I Grulkowski, JJ Liu, JG Fujimoto, H Ishikawa and G Wollstein
  • Investigative Ophthalmology and Visual Science, 58(3), 1751-1757, March 2017.
image
  • Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility
  • KA Lucy, B Wang, JS Schuman, RA Bilonick, Y Ling, L Kagemann, IA Sigal, I Grulkowski, JJ Liu, JG Fujimoto, H Ishikawa and G Wollstein
  • Investigative Ophthalmology and Visual Science, 58(3), 1751-1757, March 2017.
image
  • An imaged-based inverse finite element method to determine in-vivo mechanical properties of human trabecular meshwork
  • AD Pant, L Kagemann, JS Schuman, IA Sigal and R Amini
  • Journal for Modeling in Ophthalmology, 1(3), 100-111, 2017.
image
  • An imaged-based inverse finite element method to determine in-vivo mechanical properties of human trabecular meshwork
  • AD Pant, L Kagemann, JS Schuman, IA Sigal and R Amini
  • Journal for Modeling in Ophthalmology, 1(3), 100-111, 2017.
image
  • Biomechanical aspects of axonal damage in glaucoma: A brief review
  • C Stowell, CF Burgoyne, ER Tamm, CR Ethier, JE Dowling, JC Downs, MH Ellisman, S Fisher, B Fortune, M Fruttiger, T Jakobs, G Lewis, CH Mitchell, J Morrison, SC Sharma, IA Sigal, M Sofroniew, L Wang, J Wiggs, S Wu and RH Masland
  • Experimental eye research, 157, 13-19, April 2017.
image
  • Biomechanical aspects of axonal damage in glaucoma: A brief review
  • C Stowell, CF Burgoyne, ER Tamm, CR Ethier, JE Dowling, JC Downs, MH Ellisman, S Fisher, B Fortune, M Fruttiger, T Jakobs, G Lewis, CH Mitchell, J Morrison, SC Sharma, IA Sigal, M Sofroniew, L Wang, J Wiggs, S Wu and RH Masland
  • Experimental eye research, 157, 13-19, April 2017.
image
  • Biological aspects of axonal damage in glaucoma: A brief review
  • ER Tamm, CR Ethier, CF Burgoyne, CR Ethier, ER Tamm, C Stowell, JE Dowling, JC Downs, MH Ellisman, S Fisher, B Fortune, M Fruttiger, T Jakobs, G Lewis, CH Mitchell, J Morrison, SC Sharma, IA Sigal, M Sofroniew, L Wang, J Wiggs, S Wu and RH Masland
  • Experimental eye research, 157, 5-12, April 2017.
image
  • Biological aspects of axonal damage in glaucoma: A brief review
  • ER Tamm, CR Ethier, CF Burgoyne, CR Ethier, ER Tamm, C Stowell, JE Dowling, JC Downs, MH Ellisman, S Fisher, B Fortune, M Fruttiger, T Jakobs, G Lewis, CH Mitchell, J Morrison, SC Sharma, IA Sigal, M Sofroniew, L Wang, J Wiggs, S Wu and RH Masland
  • Experimental eye research, 157, 5-12, April 2017.
image
  • Correlation between cerebral hemodynamic and perfusion pressure changes in non-human primates
  • A Ruesch, MA Smith, G Wollstein, IA Sigal, S Nelson and JM Kainerstorfer
  • Proceeding of SPIE, Optical Tomography and Spectroscopy of Tissue XII, 100591P, February 2017.
image
  • Correlation between cerebral hemodynamic and perfusion pressure changes in non-human primates
  • A Ruesch, MA Smith, G Wollstein, IA Sigal, S Nelson and JM Kainerstorfer
  • Proceeding of SPIE, Optical Tomography and Spectroscopy of Tissue XII, 100591P, February 2017.
image
  • Mapping in-vivo optic nerve head strains caused by intraocular and intracranial pressures
  • H Tran, J Grimm, B Wang, MA Smith, A Gogola, S Nelson, E Tyler-Kabara, J Schuman, G Wollstein and IA Sigal
  • Proceeding of SPIE, Optical Elastography and Tissue Biomechanics IV, 100670B, February 2017.
image
  • Mapping in-vivo optic nerve head strains caused by intraocular and intracranial pressures
  • H Tran, J Grimm, B Wang, MA Smith, A Gogola, S Nelson, E Tyler-Kabara, J Schuman, G Wollstein and IA Sigal
  • Proceeding of SPIE, Optical Elastography and Tissue Biomechanics IV, 100670B, February 2017.
image
  • Collagen architecture of the posterior pole; high-resolution, wide-field-of-view visualization and analysis using polarized light microscopy
  • NJ Jan, K Lathrop and IA Sigal
  • Investigative Ophthalmology and Visual Science, 58(2), 735744, February 2017.
image
  • Collagen architecture of the posterior pole; high-resolution, wide-field-of-view visualization and analysis using polarized light microscopy
  • NJ Jan, K Lathrop and IA Sigal
  • Investigative Ophthalmology and Visual Science, 58(2), 735744, February 2017.
image
  • Identifying the Palisades of Vogt in Human Ex-vivo Tissue
  • IA Sigal, J Steele, S Drexler and KL Lathrop
  • The Ocular Surface 14(4), 435-439, August 2016.
image
  • Identifying the Palisades of Vogt in Human Ex-vivo Tissue
  • IA Sigal, J Steele, S Drexler and KL Lathrop
  • The Ocular Surface 14(4), 435-439, August 2016.
image
  • Non-invasive MRI Assessments of Tissue Microstructures and Macromolecules in the Eye upon Biomechanical or Biochemical Modulation
  • LC Ho, IA Sigal, NJ Jan, X Yang, Y Van der Merwe, Y Yu, Y Chau, CK Leung, IP Conner, T Jin, EX Wu, SG Kim, G Wollstein, JS Schuman and KC Chan
  • Scientific Reports, 6(1), 1-14, August 2016.
image
  • Non-invasive MRI Assessments of Tissue Microstructures and Macromolecules in the Eye upon Biomechanical or Biochemical Modulation
  • LC Ho, IA Sigal, NJ Jan, X Yang, Y Van der Merwe, Y Yu, Y Chau, CK Leung, IP Conner, T Jin, EX Wu, SG Kim, G Wollstein, JS Schuman and KC Chan
  • Scientific Reports, 6(1), 1-14, August 2016.
image
  • Experimental glaucoma causes optic nerve head neural rim tissue compression: a potentially important mechanism of axon injury
  • B Fortune, J Reynaud, C Hardin, L Wang, IA Sigal and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 57(10), 4403-4411, August 2016.
image
  • Experimental glaucoma causes optic nerve head neural rim tissue compression: a potentially important mechanism of axon injury
  • B Fortune, J Reynaud, C Hardin, L Wang, IA Sigal and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 57(10), 4403-4411, August 2016.
image
  • What is a typical optic nerve head?
  • AP Voorhees, JL Grimm, RA Bilonick, L Kagemann, H Ishikawa, JS Schuman, G Wollstein, IA Sigal
  • Experimental Eye Research, 149, 40-47, June 2016.
image
  • What is a typical optic nerve head?
  • AP Voorhees, JL Grimm, RA Bilonick, L Kagemann, H Ishikawa, JS Schuman, G Wollstein, IA Sigal
  • Experimental Eye Research, 149, 40-47, June 2016.
image
  • Decreased lamina cribrosa beam thickness and pore diameter relative to distance from the central retinal vessel trunk
  • B Wang, KA Lucy, JS Schuman, IA Sigal, RA Bilonick, L Kagemann, T Kostanyan, C Lu, J Liu, I Grulkowski, JG Fujimoto, H Ishikawa, G Wollstein
  • Investigative Ophthalmology and Visual Science, 57(7), 3088-3092, June 2016.
image
  • Decreased lamina cribrosa beam thickness and pore diameter relative to distance from the central retinal vessel trunk
  • B Wang, KA Lucy, JS Schuman, IA Sigal, RA Bilonick, L Kagemann, T Kostanyan, C Lu, J Liu, I Grulkowski, JG Fujimoto, H Ishikawa, G Wollstein
  • Investigative Ophthalmology and Visual Science, 57(7), 3088-3092, June 2016.
image
  • Regionally Discrete Aqueous Humor Outflow Quantification Using Fluorescein Canalograms
  • RT Loewen, EN Brown, P Roy, JS Schuman, IA Sigal and NA Loewen
  • PLoS ONE, 11(3), e0151754, March 2016.
image
  • Regionally Discrete Aqueous Humor Outflow Quantification Using Fluorescein Canalograms
  • RT Loewen, EN Brown, P Roy, JS Schuman, IA Sigal and NA Loewen
  • PLoS ONE, 11(3), e0151754, March 2016.
image
  • A Problem of Proportions in OCT-based Morphometry and a Proposed Solution
  • IA Sigal, JS Schuman, H Ishikawa, L Kagemann and G Wollstein
  • Investigative Ophthalmology and Visual Science, 57(2), 484-485, Feburary 2016.
  • (Letter to the Editor)
image
  • A Problem of Proportions in OCT-based Morphometry and a Proposed Solution
  • IA Sigal, JS Schuman, H Ishikawa, L Kagemann and G Wollstein
  • Investigative Ophthalmology and Visual Science, 57(2), 484-485, Feburary 2016.
  • (Letter to the Editor)
image
  • MAPS – A Magic Angle Positioning System for Enhanced Imaging in High-Field Small-Bore MRI
  • A Squires, KC Chan, LC Ho, IA Sigal, NJ Jan and ZTH Tse
  • Journal of Medical Robotics Research 1(1), 1640004, April 2016.
  • [Link]
image
  • MAPS – A Magic Angle Positioning System for Enhanced Imaging in High-Field Small-Bore MRI
  • A Squires, KC Chan, LC Ho, IA Sigal, NJ Jan and ZTH Tse
  • Journal of Medical Robotics Research 1(1), 1640004, April 2016.
image
  • Use and Misuse of Laplace’s Law in Ophthalmology
  • CW Chung, MJA Girard, NJ Jan and IA Sigal
  • Investigative Ophthalmology and Visual Science, 57(1), 236-245, January 2016.
image
  • Use and Misuse of Laplace’s Law in Ophthalmology
  • CW Chung, MJA Girard, NJ Jan and IA Sigal
  • Investigative Ophthalmology and Visual Science, 57(1), 236-245, January 2016.
image
  • Polarization Microscopy for Characterizing Fiber Orientation of Ocular Tissues
  • NJ Jan, JL Grimm, H Tran, KL Lathrop, G Wollstein, RA Bilonick, H Ishikawa, L Kagemann, JS Schuman and IA Sigal
  • Biomedical Optics Express, 6(12), 4705-4718, December 2015.
image
  • Polarization Microscopy for Characterizing Fiber Orientation of Ocular Tissues
  • NJ Jan, JL Grimm, H Tran, KL Lathrop, G Wollstein, RA Bilonick, H Ishikawa, L Kagemann, JS Schuman and IA Sigal
  • Biomedical Optics Express, 6(12), 4705-4718, December 2015.
image
  • Translating Ocular Biomechanics into Clinical Practice: Current State and Future Prospects
  • MJA Girard, WJ Dupps, M Baskaran, G Scarcelli, SH Yun, HA Quigley, IA Sigal and NG Strouthidis
  • Current Eye Research, 40(1), 1-18, Jan 2015.
image
  • Translating Ocular Biomechanics into Clinical Practice: Current State and Future Prospects
  • MJA Girard, WJ Dupps, M Baskaran, G Scarcelli, SH Yun, HA Quigley, IA Sigal and NG Strouthidis
  • Current Eye Research, 40(1), 1-18, Jan 2015.
image
  • Glaucomatous cupping of the lamina cribrosa: A review of the evidence for active progressive remodeling as a mechanism
  • JC Downs, MD Roberts and IA Sigal
  • Experimental Eye Research, 93(2), 133-140, August 2011.
image
  • Glaucomatous cupping of the lamina cribrosa: A review of the evidence for active progressive remodeling as a mechanism
  • JC Downs, MD Roberts and IA Sigal
  • Experimental Eye Research, 93(2), 133-140, August 2011
image
  • In Vivo Evaluation of White Matter Inegrity and Anterograde Transport in Visual Systems After Excitoxic Retinal Injury with Multimodal MRI and OCT
  • LC Ho, B Wang, IP Conner, Y Van der Merwe, RA Bilonick, SG Kim, EX Wu, IA Sigal, G Wollstein, JS Schuman and KC Chan
  • Investigative Ophthalmology and Visual Science, 56(6), 3788-3800, June 2015.
image
  • In Vivo Evaluation of White Matter Inegrity and Anterograde Transport in Visual Systems After Excitoxic Retinal Injury with Multimodal MRI and OCT
  • LC Ho, B Wang, IP Conner, Y Van der Merwe, RA Bilonick, SG Kim, EX Wu, IA Sigal, G Wollstein, JS Schuman and KC Chan
  • Investigative Ophthalmology and Visual Science, 56(6), 3788-3800, June 2015.
image
  • Histogram Matching Extends Acceptable Signal Strength Range on Optical Coherence Tomography Images
  • CL Chen, H Ishikawa, G Wollstein, RA Bilonick, IA Sigal, L Kagemann and JS Schuman
  • Investigative Ophthalmology and Visual Science, 56(6), 3810-3819, June 2015.
image
  • Histogram Matching Extends Acceptable Signal Strength Range on Optical Coherence Tomography Images
  • CL Chen, H Ishikawa, G Wollstein, RA Bilonick, IA Sigal, L Kagemann and JS Schuman
  • Investigative Ophthalmology and Visual Science, 56(6), 3810-3819, June 2015.
image
  • Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
  • L Kagemann, B Wang, G Wollstein, H Ishikawa, B Mentley, IA Sigal, RA Bilonick and JS Schuman
  • Journal of Visualized Experiments, 20(100), e52611, June 2015.
image
  • Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
  • L Kagemann, B Wang, G Wollstein, H Ishikawa, B Mentley, IA Sigal, RA Bilonick and JS Schuman
  • Journal of Visualized Experiments, 20(100), e52611, June 2015.
image
  • Parameters for lithium treatment are critical in its enhancement of fracture-healing in rodents
  • J Bernick, Y Wang, IA Sigal, BA Alman, CM Whyne and D Nam
  • The Journal of bone and joint surgery. American volume, 96(23), 1990-1998, December 2014.
image
  • Parameters for lithium treatment are critical in its enhancement of fracture-healing in rodents
  • J Bernick, Y Wang, IA Sigal, BA Alman, CM Whyne and D Nam
  • The Journal of bone and joint surgery. American volume, 96(23), 1990-1998, December 2014.
image
  • Application of Elliptic Fourier Analysis to Describe the Lamina Cribrosa Shape with Age and Intraocular Pressure
  • PG Sanfilippo, JL Grimm, JG Flanagan, KL Lathrop and IA Sigal
  • Experimental Eye Research, 128, 1-7, November 2014.
image
  • Application of Elliptic Fourier Analysis to Describe the Lamina Cribrosa Shape with Age and Intraocular Pressure
  • PG Sanfilippo, JL Grimm, JG Flanagan, KL Lathrop and IA Sigal
  • Experimental Eye Research, 128, 1-7, November 2014.
image
  • In Vivo Three-Dimensional Characterization of the Healthy Human Lamina Cribrosa with Adaptive Optics Spectral-Domain Optical Coherence Tomography
  • Z Nadler, B Wang, JS Schuman, RD Ferguson, A Patel, DX Hammer, RA Bilonick, H Ishikawa, L Kagemann, IA Sigal and G Wollstein
  • Investigative Ophthalmology and Visual Science, 55(10), 6459-6466, October 2014.
image
  • In Vivo Three-Dimensional Characterization of the Healthy Human Lamina Cribrosa with Adaptive Optics Spectral-Domain Optical Coherence Tomography
  • Z Nadler, B Wang, JS Schuman, RD Ferguson, A Patel, DX Hammer, RA Bilonick, H Ishikawa, L Kagemann, IA Sigal and G Wollstein
  • Investigative Ophthalmology and Visual Science, 55(10), 6459-6466, October 2014.
image
  • Magic Angle-Enhanced MRI Of Fibrous Microstructures In Sclera And Cornea With And Without Intraocular Pressure Loading
  • *LC Ho, *IA Sigal, NJ Jan, A Squires, Z Tse, EX Wu, SG Kim, JS Schuman and KC Chan
  • Investigative Ophthalmology and Visual Science, 55(9), 5662-5672, September 2014.
  • (* Authors contributed equally to this manuscript)
image
  • Magic Angle-Enhanced MRI Of Fibrous Microstructures In Sclera And Cornea With And Without Intraocular Pressure Loading
  • *LC Ho, *IA Sigal, NJ Jan, A Squires, Z Tse, EX Wu, SG Kim, JS Schuman and KC Chan
  • Investigative Ophthalmology and Visual Science, 55(9), 5662-5672, September 2014.
  • (* Authors contributed equally to this manuscript)
image
  • Recent Advances in OCT Imaging of the Lamina Cribrosa
  • IA Sigal, B Wang, NG Strouthidis, T Akagi and MJA Girard
  • British Journal of Ophthalmology, 98(Suppl 2), ii34-ii39, July 2014.
image
  • Recent Advances in OCT Imaging of the Lamina Cribrosa
  • IA Sigal, B Wang, NG Strouthidis, T Akagi and MJA Girard
  • British Journal of Ophthalmology, 98(Suppl 2), ii34-ii39, June 2014.
image
  • Characterization of Schlemm’s Canal Cross-Sectional Area
  • L Kagemann, JE Nevins, NJ Jan, G Wollstein, H Ishikawa, J Kagemann, IA Sigal, Z Nadler, Y Ling and JS Schuman
  • British Journal of Ophthalmology, 98(Suppl 2), ii10-ii14, June 2014.
image
  • Characterization of Schlemm’s Canal Cross-Sectional Area
  • L Kagemann, JE Nevins, NJ Jan, G Wollstein, H Ishikawa, J Kagemann, IA Sigal, Z Nadler, Y Ling and JS Schuman
  • British Journal of Ophthalmology, 98(Suppl 2), ii10-ii14, June 2014.
image
  • A Method to Estimate Biomechanics and Mechanical Properties of Optic Nerve Head Tissues From Parameters Measurable Using Optical Coherence Tomography
  • IA Sigal, JL Grimm, JS Schuman, L Kagemann, H Ishikawa and G Wollstein
  • IEEE Transactions on Medical Imaging, 33(6), 1381-1389, June 2014.
image
  • A Method to Estimate Biomechanics and Mechanical Properties of Optic Nerve Head Tissues From Parameters Measurable Using Optical Coherence Tomography
  • IA Sigal, JL Grimm, JS Schuman, L Kagemann, H Ishikawa and G Wollstein
  • IEEE Transactions on Medical Imaging, 33(6), 1381-1389, June 2014.
image
  • Reproducibility of In-Vivo OCT Measured Three-Dimensional Human Lamina Cribrosa Microarchitecture
  • B Wang, JE Nevins, Z Nadler, G Wollstein, H Ishikawa, RA Bilonick, L Kagemann, IA Sigal, I Grulkowski, JJ Liu, M Kraus, CD Lu, J Hornegger, JG Fujimoto and JS Schuman
  • PLoS ONE, 9(4), e95526, April 2014.
image
  • Reproducibility of In-Vivo OCT Measured Three-Dimensional Human Lamina Cribrosa Microarchitecture
  • B Wang, JE Nevins, Z Nadler, G Wollstein, H Ishikawa, RA Bilonick, L Kagemann, IA Sigal, I Grulkowski, JJ Liu, M Kraus, CD Lu, J Hornegger, JG Fujimoto and JS Schuman
  • PLoS ONE, 9(4), e95526, April 2014.
image
  • IOP Elevation Reduces Schlemm’s Canal Cross-sectional Area
  • L Kagemann, B Wang, G Wollstein, H Ishikawa, JE Nevins, Z Nadler, IA Sigal, RA Bilonick and JS Schuman
  • Investigative Ophthalmology and Visual Science, 55(3), 1805-1809, March 2014.
image
  • IOP Elevation Reduces Schlemm’s Canal Cross-sectional Area
  • L Kagemann, B Wang, G Wollstein, H Ishikawa, JE Nevins, Z Nadler, IA Sigal, RA Bilonick and JS Schuman
  • Investigative Ophthalmology and Visual Science, 55(3), 1805-1809, March 2014.
image
  • Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography
  • Z Nadler, B Wang, G Wollstein, JE Nevins, H Ishikawa, R Bilonick, L Kagemann, IA Sigal, RD Ferguson, A Patel, DX Hammer and JS Schuman
  • Biomedical Optics Express, 5(4), 1114-1123, April 2014.
image
  • Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography
  • Z Nadler, B Wang, G Wollstein, JE Nevins, H Ishikawa, R Bilonick, L Kagemann, IA Sigal, RD Ferguson, A Patel, DX Hammer and JS Schuman
  • Biomedical Optics Express, 5(4), 1114-1123, April 2014.
image
  • Gold Nanorods as a Contrast Agent for Doppler Optical Coherence Tomography
  • B Wang, L Kagemann, JS Schuman, H Ishikawa, RA Bilonick, Y Ling, IA Sigal, Z Nadler, A Francis, MG Sandrian and G Wollstein
  • PLoS One, 9(3), e90690, March 2014.
image
  • Gold Nanorods as a Contrast Agent for Doppler Optical Coherence Tomography
  • B Wang, L Kagemann, JS Schuman, H Ishikawa, RA Bilonick, Y Ling, IA Sigal, Z Nadler, A Francis, MG Sandrian and G Wollstein
  • PLoS One, 9(3), e90690, March 2014.
image
  • Eye-Specific IOP-Induced Displacements and Deformations of Human Lamina Cribrosa
  • IA Sigal, JL Grimm, NJ Jan, K Reid, DS Minckler and DJ Brown
  • Investigative Ophthalmology and Visual Science, 55(1), 1-15, January 2014.
image
  • Eye-Specific IOP-Induced Displacements and Deformations of Human Lamina Cribrosa
  • IA Sigal, JL Grimm, NJ Jan, K Reid, DS Minckler and DJ Brown
  • Investigative Ophthalmology and Visual Science, 55(1), 1-15, January 2014.
image
  • In-Vivo Lamina Cribrosa Microarchitecture in Healthy and Glaucomatous Eyes as Assessed by Optical Coherence Tomography
  • B Wang, JE Nevins, Z Nadler, G Wollstein, H Ishikawa, RA Bilonick, L Kagemann, IA Sigal, I Grulkowski, JJ Liu, M Kraus, CD Lu, J Hornegger, JG Fujimoto and JS Schuman
  • Investigative Ophthalmology and Visual Science, 54(13), 8270-8274, December 2013.
image
  • In-Vivo Lamina Cribrosa Microarchitecture in Healthy and Glaucomatous Eyes as Assessed by Optical Coherence Tomography
  • B Wang, JE Nevins, Z Nadler, G Wollstein, H Ishikawa, RA Bilonick, L Kagemann, IA Sigal, I Grulkowski, JJ Liu, M Kraus, CD Lu, J Hornegger, JG Fujimoto and JS Schuman
  • Investigative Ophthalmology and Visual Science, 54(13), 8270-8274, December 2013.
image
  • Automated Lamina Cribrosa Microstructural Segmentation in Optical Coherence Tomography Scans of Healthy and Glaucomatous Eyes
  • Z Nadler, B Wang, G Wollstein, J Nevins, H Ishikawa, L Kagemann, IA Sigal, RD Ferguson, DX Hammer, I Grulkowski, JJ Liu, MF Kraus, CD Lu, J Hornegger, JG Fujimoto and JS Schuman
  • Biomedical Optics Express, 4(11), 2596-2608, November 2013.
image
  • Automated Lamina Cribrosa Microstructural Segmentation in Optical Coherence Tomography Scans of Healthy and Glaucomatous Eyes
  • Z Nadler, B Wang, G Wollstein, J Nevins, H Ishikawa, L Kagemann, IA Sigal, RD Ferguson, DX Hammer, I Grulkowski, JJ Liu, MF Kraus, CD Lu, J Hornegger, JG Fujimoto and JS Schuman
  • Biomedical Optics Express, 4(11), 2596-2608, November 2013.
image
  • Signal Normalization Reduces Systematic Measurement Differences Between Spectral Domain Optical Coherence Tomography Devices
  • CL Chen, H Ishikawa, Y Ling, G Wollstein, RA Bilonick, J Xu, JG Fujimoto, IA Sigal, L Kagemann and JS Schuman
  • Investigative Ophthalmology and Visual Science, 54(12), 7317-7322, November 2013.
image
  • Signal Normalization Reduces Systematic Measurement Differences Between Spectral Domain Optical Coherence Tomography Devices
  • CL Chen, H Ishikawa, Y Ling, G Wollstein, RA Bilonick, J Xu, JG Fujimoto, IA Sigal, L Kagemann and JS Schuman
  • Investigative Ophthalmology and Visual Science, 54(12), 7317-7322, November 2013.
image
  • Individual A-Scan Signal Normalization Between Two Spectral Domain Optical Coherence Tomography Devices
  • CL Chen, H Ishikawa, G Wollstein, Y Ling, RA Bilonick, L Kagemann, IA Sigal and JS Schuman
  • Investigative Ophthalmology and Visual Science, 54(5),3463-3471, May 2013.
image
  • Individual A-Scan Signal Normalization Between Two Spectral Domain Optical Coherence Tomography Devices
  • CL Chen, H Ishikawa, G Wollstein, Y Ling, RA Bilonick, L Kagemann, IA Sigal and JS Schuman
  • Investigative Ophthalmology and Visual Science, 54(5), 3463-3471, May 2013.
image
  • High Dynamic Range Imaging Concept-Based Signal Enhancement Method Reduced the Optical Coherence Tomography Measurement Variability
  • H Ishikawa, CL Chen, G Wollstein, JL Grimm, Y Ling, RA Bilonick, IA Sigal, L Kagemann and JS Schuman
  • Investigative Ophthalmology and Visual Science, 54(1), 836-841, January 2013.
image
  • High Dynamic Range Imaging Concept-Based Signal Enhancement Method Reduced the Optical Coherence Tomography Measurement Variability
  • H Ishikawa, CL Chen, G Wollstein, JL Grimm, Y Ling, RA Bilonick, IA Sigal, L Kagemann and JS Schuman
  • Investigative Ophthalmology and Visual Science, 54(1):836-41, Jan 2013. PMID 23299477.
image
  • Human Lamina Cribrosa Insertion and Age
  • IA Sigal, JG Flanagan, KL Lathrop, I Tertinegg and R Bilonick
  • Investigative Ophthalmology and Visual Science, 53(11), 6780-6789, October 2012.
image
  • Human Lamina Cribrosa Insertion and Age
  • IA Sigal, JG Flanagan, KL Lathrop, I Tertinegg and R Bilonick
  • Investigative Ophthalmology and Visual Science, 53(11):6780-9, Oct 2012. PMID 22956611.
image
  • Morphometric Analysis of Aqueous Humor Outflow Structures with Spectral Domain Optical Coherence Tomography
  • AW Francis, L Kagemann, G Wollstein, H Ishikawa, S Folz, D Overby, IA Sigal, B Wang and JS Schuman
  • Investigative Ophthalmology and Visual Science, 53(9), 5198-207, September 2012.
image
  • Morphometric Analysis of Aqueous Humor Outflow Structures with Spectral Domain Optical Coherence Tomography
  • AW Francis, L Kagemann, G Wollstein, H Ishikawa, S Folz, D Overby, IA Sigal, B Wang and JS Schuman
  • Invest Opthalmol Vis Sci, 53(9):5198-207, September 2012.
image
  • Visualization of the Conventional Outflow Pathway in the Living Human Eye
  • L Kagemann, G Wollstein, H Ishikawa, Z Nadler, IA Sigal, LS Folio and JS Schuman
  • Ophthalmology, 119(8), 1563-1568, August 2012.
image
  • Visualization of the Conventional Outflow Pathway in the Living Human Eye
  • L Kagemann, G Wollstein, H Ishikawa, Z Nadler, IA Sigal, LS Folio and JS Schuman
  • Ophthalmology, 119(8), 1563-1568, August 2012.
image
  • A few good responses. Which mechanical effects of IOP on the ONH to study?
  • IA Sigal, JL Grimm
  • Investigative Ophthalmology and Visual Science, 53(7), 4270-4278, June 2012.
image
  • A few good responses. Which mechanical effects of IOP on the ONH to study?
  • IA Sigal, JL Grimm
  • Investigative Ophthalmology and Visual Science, 53(7), 4270-4278, June 2012.
image
  • The Optic Nerve Head As A Robust Biomechanical System
  • IA Sigal,RA Bilonick, L Kagemann, G Wollstein, H Ishikawa, JS Schuman and JL Grimm
  • Investigative Ophthalmology and Visual Science, 53(6), 2658-2667, May 2012.
image
  • The Optic Nerve Head As A Robust Biomechanical System
  • IA Sigal,RA Bilonick, L Kagemann, G Wollstein, H Ishikawa, JS Schuman and JL Grimm
  • Investigative Ophthalmology and Visual Science, 53(6), 2658-2667, May 2012.
image
  • Lamina Cribrosa Thickening in Early Glaucoma Predicted by a Microstructure Driven Growth and Remodeling Approach
  • R Grytz, IA Sigal, JW Ruberti, G Meschke and JC Downs
  • Mechanics of Materials, 44, 99-109, January 2012.
image
  • Lamina Cribrosa Thickening in Early Glaucoma Predicted by a Microstructure Driven Growth and Remodeling Approach
  • R Grytz, IA Sigal, JW Ruberti, G Meschke and JC Downs
  • Mechanics of Materials, 44, 99-109, January 2012.
image
  • Effect of Acute Intraocular Pressure Elevation on the Monkey Optic Nerve Head as Detected by Spectral Domain Ocular Coherence Tomography
  • NG Strouthidis, B Fortune, H Yang, IA Sigal and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 52(12), 9431-9437, December 2011.
image
  • Effect of Acute Intraocular Pressure Elevation on the Monkey Optic Nerve Head as Detected by Spectral Domain Ocular Coherence Tomography
  • NG Strouthidis, B Fortune, H Yang, IA Sigal and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 52(12), 9431-9437, December 2011.
image
  • IOP-induced lamina cribrosa displacement and scleral canal expansion. Are they independent or related?
  • IA Sigal, H Yang, MD Roberts, JL Grimm, CF Burgoyne, S Demirel and JC Downs
  • Investigative Ophthalmology and Visual Science, 52(12), 9023-9032. December 2011.
image
  • IOP-induced lamina cribrosa displacement and scleral canal expansion. Are they independent or related?
  • IA Sigal, H Yang, MD Roberts, JL Grimm, CF Burgoyne, S Demirel and JC Downs
  • Investigative Ophthalmology and Visual Science, 52(12), 9023-9032. December 2011.
image
  • 3D Visualization of Aqueous Outflow Structures In the Living Human Eye
  • L Kagemann, G Wollstein, H Ishikawa, Z Nadler, IA Sigal, LS Folio, J Xu, H Gong and JS Schuman
  • Experimental eye research, 93(3), 308-315, September 2011.
  • Camras Special Issue
image
  • 3D Visualization of Aqueous Outflow Structures In the Living Human Eye
  • L Kagemann, G Wollstein, H Ishikawa, Z Nadler, IA Sigal, LS Folio, J Xu, H Gong and JS Schumann
  • Experimental eye research, 93(3), 308-315, September 2011.
  • Camras Special Issue
image
  • Posterior (outward) migration of the lamina cribrosa and early cupping in monkey experimental glaucoma
  • H Yang, G Williams, JC Downs, IA Sigal, MD Roberts, H Thompson and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 52(10), 7109-7921, September 2011.
image
  • Posterior (outward) migration of the lamina cribrosa and early cupping in monkey experimental glaucoma
  • H Yang, G Williams, JC Downs, IA Sigal, MD Roberts, H Thompson and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 52(10), 7109-7921, September 2011.
image
  • An Applet to Estimate the IOP-Induced Stress and Strain Within the Optic Nerve Head
  • IA Sigal
  • Investigative Ophthalmology and Visual Science, 52(8), 5497-5506, July 2011.
image
  • An Applet to Estimate the IOP-Induced Stress and Strain Within the Optic Nerve Head
  • IA Sigal
  • Investigative Ophthalmology and Visual Science, 52(8), 5497-5506, July 2011.
image
  • Finite Element Modeling of the Human Sclera: Influence on Optic Nerve Head Biomechanics and Connections with Glaucoma
  • R Norman, JG Flanagan, IA Sigal, S Rausch, I Tertinegg and CR Ethier
  • Experimental Eye Research, 93(1), July 2011.
image
  • Finite Element Modeling of the Human Sclera: Influence on Optic Nerve Head Biomechanics and Connections with Glaucoma
  • R Norman, JG Flanagan, IA Sigal, S Rausch, I Tertinegg and CR Ethier
  • Experimental Eye Research, 93(1), July 2011.
image
  • IOP-Induced Lamina Cribrosa Displacement and Scleral Canal Expansion: an Analysis of Factor Interactions Using Parameterized Eye-Specific Models
  • IA Sigal, H Yang, MD Roberts, CF Burgoyne and JC Downs
  • Investigative Ophthalmology and Visual Science, 52(3), 1896-1907, March 2011.
image
  • IOP-Induced Lamina Cribrosa Displacement and Scleral Canal Expansion: an Analysis of Factor Interactions Using Parameterized Eye-Specific Models
  • IA Sigal, H Yang, MD Roberts, CF Burgoyne and JC Downs
  • Investigative Ophthalmology and Visual Science, 52(3), 1896-1907, March 2011.
image
  • Longitudinal Change Detected by Spectral Domain Optical Coherence Tomography in the Glaucomatous Optic Nerve Head and Peripapillary Retina
  • NG Strouthidis, B Fortune, H Yang, IA Sigal and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 52(3), 1206-1219, March 2011.
image
  • Longitudinal Change Detected by Spectral Domain Optical Coherence Tomography in the Glaucomatous Optic Nerve Head and Peripapillary Retina
  • NG Strouthidis, B Fortune, H Yang, IA Sigal and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 52(3), 1206-19, March 2011.
image
  • Deformation of the Early Glaucomatous Monkey Optic Nerve Head Connective Tissue Following Acute IOP Elevation Within 3-D Histomorphometric Reconstructions
  • H Yang, H Thompson, MD Roberts, IA Sigal, JC Downs and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 52(1), 345-363, January 2011.
image
  • Deformation of the Early Glaucomatous Monkey Optic Nerve Head Connective Tissue Following Acute IOP Elevation Within 3-D Histomorphometric Reconstructions
  • H Yang, H Thompson, MD Roberts, IA Sigal, JC Downs and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 52(1), 345-363, January 2011.
image
  • Changes in the Biomechanical Response of the Optic Nerve Head in Early Experimental Glaucoma
  • MD Roberts, IA Sigal, Yi Liang, CF Burgoyne and JC Downs
  • Investigative Ophthalmology and Visual Science, 51(11):5675-5684. November 2010, PMID 20538997
image
  • Changes in the Biomechanical Response of the Optic Nerve Head in Early Experimental Glaucoma
  • MD Roberts, IA Sigal, Yi Liang, CF Burgoyne and JC Downs
  • Investigative Ophthalmology and Visual Science, 51(11):5675-5684. November 2010, PMID 20538997
image
  • A Geometric Morphometric Assessment of the Optic Cup in Glaucoma
  • PG Sanfilippo, A Cardini, IA Sigal, J Ruddle, BE Chua, AW Hewitt, and DA Mackey
  • Experimental Eye Research, 91(3), 405-414, September 2010.
image
  • A Geometric Morphometric Assessment of the Optic Cup in Glaucoma
  • PG Sanfilippo, A Cardini, IA Sigal, J Ruddle, BE Chua, AW Hewitt, and DA Mackey
  • Experimental Eye Research, 91(3), 405-414, September 2010.
image
  • Biomechanical Changes of the Optic Disc
  • IA Sigal, MD Roberts, MJA Girard, CF Burgoyne and JC Down
  • Ocular Disease: Mechanisms and Management Eds: LA Levin and DM Albert, Saunders (Elsevier), Chapter 20, 704, March 2010.
  • ISBN 978-0-7020-2983-7
image
  • Biomechanical Changes of the Optic Disc
  • IA Sigal, MD Roberts, MJA Girard, CF Burgoyne and JC Down
  • Ocular Disease: Mechanisms and Management Eds: LA Levin and DM Albert, Saunders (Elsevier), Chapter 20, 704, March 2010.
  • ISBN 978-0-7020-2983-7
image
  • Dimensions of the Human Sclera: Thickness Measurement and Regional Changes with Axial Length
  • R Norman, JG Flanagan, S Rausch, IA Sigal, I Tertinegg, A Eilaghi, S Portnoy, J Sled and CR Ethier
  • Experimental Eye Research, 90(2), 277-284, Feburary 2010.
image
  • Dimensions of the Human Sclera: Thickness Measurement and Regional Changes with Axial Length
  • R Norman, JG Flanagan, S Rausch, IA Sigal, I Tertinegg, A Eilaghi, S Portnoy, J Sled and CR Ethier
  • Experimental Eye Research, 90(2), 277-284, Feburary 2010.
image
  • 3D morphometry of the Human Optic Nerve Head
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Experimental Eye Research, 90(1), 70-80, January 2010.
image
  • 3D morphometry of the Human Optic Nerve Head
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Experimental Eye Research, 90(1), 70-80, January 2010.
image
  • Mesh Morphing and Response Surface Analysis: Quantifying Sensitivity of Vertebral Mechanical Behaviour
  • IA Sigal and CM Whyne
  • Annals of Biomedical Engineering, 38(1), 41-56, January 2010.
image
  • Mesh Morphing and Response Surface Analysis: Quantifying Sensitivity of Vertebral Mechanical Behaviour
  • IA Sigal and CM Whyne
  • Annals of Biomedical Engineering, 38(1), 41-56, January 2010.
image
  • Morphing Methods to Parameterize Specimen-Specific Finite Element Model Geometries
  • IA Sigal, H Yang, MD Roberts and JC Downs
  • Journal of Biomechanics, 43(2), 254-262, Jan 2010.
image
  • Morphing Methods to Parameterize Specimen-Specific Finite Element Model Geometries
  • IA Sigal, H Yang, MD Roberts and JC Downs
  • Journal of Biomechanics, 43(2), 254-262, Jan 2010.
image
  • Correlation Between Local Stress and Strain and Lamina Cribrosa Connective Tissue Volume Fraction in Normal Monkey Eyes
  • MD Roberts, Y Liang, IA Sigal, J Grimm, J Reynaud, A Bellezza, CF Burgoyne and JC Downs
  • Investigative Ophthalmology and Visual Science, 51(1), 295-307, January 2010.
image
  • Correlation Between Local Stress and Strain and Lamina Cribrosa Connective Tissue Volume Fraction in Normal Monkey Eyes
  • MD Roberts, Y Liang, IA Sigal, J Grimm, J Reynaud, A Bellezza, CF Burgoyne and JC Downs
  • Investigative Ophthalmology and Visual Science, 51(1), 295-307, January 2010.
image
  • Deformation of the Normal Monkey Optic Nerve Head Connective Tissues Following Acute IOP Elevation Within 3-D Histomorphometric Reconstructions
  • H Yang, JC Downs, IA Sigal, M Roberts, H Thompson, CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 50(12), 5785-5789. December 2009.
image
  • Deformation of the Normal Monkey Optic Nerve Head Connective Tissues Following Acute IOP Elevation Within 3-D Histomorphometric Reconstructions
  • H Yang, JC Downs, IA Sigal, M Roberts, H Thompson, CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 50(12), 5785-5789. December 2009.
image
  • Interactions Between Geometry and Mechanical Properties on the Optic Nerve Head
  • IA Sigal
  • Investigative Ophthalmology and Visual Science, 50(6), 2785-2795, June 2009.
image
  • Interactions Between Geometry and Mechanical Properties on the Optic Nerve Head
  • IA Sigal
  • Investigative Ophthalmology and Visual Science, 50(6), 2785-2795, June 2009.
image
  • Biomechanics of the Optic Nerve Head
  • IA Sigal, CR Ethier
  • Experimental Eye Research, 88(4), 799-807, April 2009.
image
  • Biomechanics of the Optic Nerve Head
  • IA Sigal, CR Ethier
  • Experimental Eye Research, 88(4), 799-807, April 2009.
image
  • Modeling Individual-Specific Human Optic Nerve Head Biomechanics Part II: Influence of Material Properties
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Biomechanics and Modeling in Mechanobiology, 8(2), 99-109, April 2009.
image
  • Modeling Individual-Specific Human Optic Nerve Head Biomechanics Part II: Influence of Material Properties
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Biomechanics and Modeling in Mechanobiology, 8(2), 99-109, April 2009.
image
  • Modeling Individual-Specific Human Optic Nerve Head Biomechanics Part I: IOP-Induced Deformations and Influence of Geometry
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Biomechanics and Modeling in Mechanobiology, 8(2), 85-98, April 2009.
image
  • Modeling Individual-Specific Human Optic Nerve Head Biomechanics Part I: IOP-Induced Deformations and Influence of Geometry
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Biomech Model Mechanobiol, 8(2), 85-98, Apr 2009.
image
  • Mesh-Morphing Algorithms for Specimen-Specific Finite Element Modeling
  • IA Sigal, MR Hardisty and CM Whyne
  • Journal of Biomechanics, 41(7), 1381-1389, April 2008.
image
  • Mesh-Morphing Algorithms for Specimen-Specific Finite Element Modeling
  • IA Sigal, MR Hardisty and CM Whyne
  • Journal of Biomechanics, 41(7), 1381-1389, April 2008.
image
  • Predicted Extension, Compression and Shearing of Optic Nerve Head Tissues
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Experimental Eye Research, 85(3), 312-322, September 2007.
image
  • Predicted Extension, Compression and Shearing of Optic Nerve Head Tissues
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Experimental Eye Research, 85(3), 312-322, September 2007.
image
  • Factors Influencing Human Optic Nerve Head Biomechanics
  • IA Sigal, JG Flanagan and CR Ethier
  • Investigative Ophthalmology and Visual Science, 46(11), 4189-4199, November 2005.
image
  • Factors Influencing Human Optic Nerve Head Biomechanics
  • IA Sigal, JG Flanagan and CR Ethier
  • Investigative Ophthalmology and Visual Science, 46(11), 4189-4199, November 2005.
image
  • Reconstruction of Human Optic Nerve Heads for Finite Element Modeling
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Technology and Health Care: Official Journal of the European Society for Engineering and Medicine, 13(4), 313-329, August 2005.
image
  • Reconstruction of Human Optic Nerve Heads for Finite Element Modeling
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Technology and Health Care: Official Journal of the European Society for Engineering and Medicine, 13(4), 313-329, August 2005.
image
  • Finite Element Modeling of Optic Nerve Head Biomechanics
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Investigative Ophthalmology and Visual Science, 45(12), 4378-4387, December 2004.
image
  • Finite Element Modeling of Optic Nerve Head Biomechanics
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Investigative Ophthalmology and Visual Science, 45(12), 4378-4387, December 2004.
image
  • Investigation Of The Biomechanical Environment Within The Optic Nerve Head By Finite Element Modelling
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Computational Fluid and Solid Mechanics, 2nd MIT Conference on, Boston, June 17-20, 2003, K.J. Bathe (ed.), pp. 1810-1813, Elsevier (ISBN: 0-08-044046-0), 2003.
image
  • Investigation Of The Biomechanical Environment Within The Optic Nerve Head By Finite Element Modelling
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Computational Fluid and Solid Mechanics, 2nd MIT Conference on, Boston, June 17-20, 2003, K.J. Bathe (ed.), pp. 1810-1813, Elsevier (ISBN: 0-08-044046-0), 2003.
image
  • Chirality in Bare and Passivated Gold Nanoclusters
  • IL Garzón, JA Reyes-Nava, JI Rodríguez-Hernández, I Sigal, MR Beltrán and K Michaelian
  • Physical Review B, 66(7), 073403, August 2002.
image
  • Chirality in Bare and Passivated Gold Nanoclusters
  • IL Garzón, JA Reyes-Nava, JI Rodríguez-Hernández, I Sigal, MR Beltrán and K Michaelian
  • Physical Review B, 66(7), 073403, August 2002.