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Ocular Biomechanics

University of Pittsburgh

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Publications

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  • Comparing continuum and direct fiber models of soft tissues. An ocular biomechanics example reveals that continuum models may artificially disrupt the strains at both the tissue and fiber levels
  • Xuehuan He, Mohammad R. Islam, Fengting Ji, Bingrui Wang, Ian A. Sigal
  • Accepted to Acta Biomaterialia October 2024.
  • [PDF,Link]
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  • Comparing continuum and direct fiber models of soft tissues. An ocular biomechanics example reveals that continuum models may artificially disrupt the strains at both the tissue and fiber levels
  • Xuehuan He, Mohammad R. Islam, Fengting Ji, Bingrui Wang, Ian A. Sigal
  • Accepted to Acta Biomaterialia October 2024.
  • [PDF,Link]
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  • Proposing a methodology for axon-centric analysis of IOP-induced mechanical insult
  • Manik Bansal, Bingrui Wang, Susannah Waxman, Fuqiang Zhong, Yi Hua, Yuankai Lu, Juan Reynaud, Brad Fortune, Ian A. Sigal.
  • Accepted to IVOS September 2024.
  • [PDF,Link]
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  • Proposing a methodology for axon-centric analysis of IOP-induced mechanical insult
  • Manik Bansal, Bingrui Wang, Susannah Waxman, Fuqiang Zhong, Yi Hua, Yuankai Lu, Juan Reynaud, Brad Fortune, Ian A. Sigal.
  • Accepted to IVOS September 2024.
  • [PDF,Link]
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  • Lamina Cribrosa Insertions Into the Sclera Are Sparser, Narrower, and More Slanted in the Anterior Lamina
  • Ji F, Islam MR, Wang B, Hua Y, Sigal IA.
  • Invest Ophthalmol Vis Sci. 2024;65(4):35. doi:10.1167/iovs.65.4.35
  • [PDF,Link]
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  • Lamina Cribrosa Insertions Into the Sclera Are Sparser, Narrower, and More Slanted in the Anterior Lamina
  • Ji F, Islam MR, Wang B, Hua Y, Sigal IA.
  • Invest Ophthalmol Vis Sci. 2024;65(4):35. doi:10.1167/iovs.65.4.35
  • [PDF,Link]
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  • The Robust Lamina Cribrosa Vasculature: Perfusion and Oxygenation Under Elevated Intraocular Pressure
  • Yuankai Lu; Yi Hua; Bingrui Wang; Fuqiang Zhong; Andrew Theophanous; Shaharoz Tahir; Po-Yi Lee; Ian A. Sigal
  • Invest Ophthalmol Vis Sci. 2024;65(5):1. doi:10.1167/iovs.65.5.1
  • [PDF,Link]
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  • The Robust Lamina Cribrosa Vasculature: Perfusion and Oxygenation Under Elevated Intraocular Pressure
  • Yuankai Lu; Yi Hua; Bingrui Wang; Fuqiang Zhong; Andrew Theophanous; Shaharoz Tahir; Po-Yi Lee; Ian A. Sigal
  • Invest Ophthalmol Vis Sci. 2024;65(5):1. doi:10.1167/iovs.65.5.1
  • [PDF,Link]
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  • Fibrous finite element modeling of the optic nerve head region
  • MR Islam, F Ji, M Bansal, Y Hua and IA Sigal
  • Acta Biomaterialia 2024;175:123-137. doi:10.1016/j.actbio.2023.12.034.
  • [PDF,Link]
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  • Fibrous finite element modeling of the optic nerve head region
  • MR Islam, F Ji, M Bansal, Y Hua and IA Sigal
  • Acta Biomaterialia 2024;175:123-137. doi:10.1016/j.actbio.2023.12.034.
  • [PDF,Link]
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  • Direct measurements of collagen fiber recruitment in the posterior pole of the eye
  • PY Lee, G Fryc, J Gnalian, Y Hua, S Waxman, F Zhong, B Yang and IA Sigal
  • Acta Biomaterialia 2024 Jan 1:173:135-147. doi: 10.1016/j.actbio.2023.11.013
  • [PDF, Journal Link]
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  • Direct measurements of collagen fiber recruitment in the posterior pole of the eye
  • PY Lee, G Fryc, J Gnalian, Y Hua, S Waxman, F Zhong, B Yang and IA Sigal
  • Acta Biomaterialia 2024 Jan 1:173:135-147. doi: 10.1016/j.actbio.2023.11.013
  • [PDF, Journal Link]
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  • 2D or not 2D? Mapping the in-depth inclination of the collagen fibers of the corneoscleral shell
  • F Ji, M Quinn, B Wang, PY Lee, and IA Sigal
  • Experimental Eye Research 2023 Dec:237:109701. doi: 10.1016/j.exer.2023.109701
  • [Link]
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  • 2D or not 2D? Mapping the in-depth inclination of the collagen fibers of the corneoscleral shell
  • F Ji, M Quinn, B Wang, PY Lee, and IA Sigal
  • Experimental Eye Research 2023 Dec:237:109701. doi: 10.1016/j.exer.2023.109701
  • [Link]
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  • A direct fiber approach to model sclera collagen architecture and biomechanics
  • F Ji, M Bansal, B Wang, Y Hua, MR Islam, F Matuschke, M Axer, and IA Sigal
  • Experimental Eye Research. 2023 Jul:232:109510. doi: 10.1016/j.exer.2023.109510
  • [PDF,Link]
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  • A direct fiber approach to model sclera collagen architecture and biomechanics
  • F Ji, M Bansal, B Wang, Y Hua, MR Islam, F Matuschke, M Axer, and IA Sigal
  • Experimental Eye Research. 2023 Jul:232:109510. doi: 10.1016/j.exer.2023.109510
  • [PDF,Link]
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  • Predatory Bacteria can Reduce Pseudomonas aeruginosa Induced Corneal Perforation and Proliferation in a Rabbit Keratitis Model  
  • EG Romanowski, NA Stella, BL Brazile, KL Lathrop, JM Franks, IA Sigal, T Kim, M Elsayed, DE Kadouri and RMQ Shanks
  • Ocul Surf. 2023 Apr:28:254-261. doi: 10.1016/j.jtos.2023.05.002
  • [PDF,Link]
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  • Predatory Bacteria can Reduce Pseudomonas aeruginosa Induced Corneal Perforation and Proliferation in a Rabbit Keratitis Model  
  • EG Romanowski, NA Stella, BL Brazile, KL Lathrop, JM Franks, IA Sigal, T Kim, M Elsayed, DE Kadouri and RMQ Shanks
  • Ocul Surf. 2023 Apr:28:254-261. doi: 10.1016/j.jtos.2023.05.002
  • [PDF,Link]
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  • Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues  
  • PY Lee, H Schilpp, N Naylor, SC Watkins, B Yang, and IA Sigal
  • Optics and Lasers in Engineering, July 2023, PMID: 36778384 doi: j.optlaseng.2023.107594
  • [PDF,Link]
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  • Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues  
  • PY Lee, H Schilpp, N Naylor, SC Watkins, B Yang, and IA Sigal
  • Optics and Lasers in Engineering, July 2023, PMID: 36778384 doi: j.optlaseng.2023.107594
  • [PDF,Link]
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  • Individual astrocyte morphology in the collagenous lamina cribrosa revealed by multicolor DiOlistic labeling
  • S Waxman, M Quinn, C Donahue, LD Falo Jr, TC Jakobs, D Sun, and IA Sigal
  • Experimental Eye Research, May 2023, PMID: 36965593 doi:2022.12.24.520184
  • [PDF,Link]
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  • Individual astrocyte morphology in the collagenous lamina cribrosa revealed by multicolor DiOlistic labeling
  • S Waxman, M Quinn, C Donahue, LD Falo Jr, TC Jakobs, D Sun, and IA Sigal
  • Experimental Eye Research, May 2023, PMID: 36965593 doi:2022.12.24.520184
  • [PDF, Link]
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  • Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell
  • TY Foong, Y Hua, R Amini, and IA Sigal
  • Experimental Eye Research, May 2023, PMID: 36935071 doi:j.exer.2023.109446.
  • [PDF,Link]
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  • Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell
  • TY Foong, Y Hua, R Amini, and IA Sigal
  • Experimental Eye Research, May 2023, PMID: 36935071 doi:j.exer.2023.109446.
  • [PDF, Link]
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  • Stretch-induced uncrimping of equatorial sclera collagen bundle
  • NJ Jan, PY Lee, J Wallace, M Iasella, A Gogola, B Wang and IA Sigal
  • ASME Journal of Biomechanical Engineering, Nov 2022, 2022.09.13.507860
  • [PDF,Link]
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  • Stretch-induced uncrimping of equatorial sclera collagen bundle
  • NJ Jan, PY Lee, J Wallace, M Iasella, A Gogola, B Wang and IA Sigal
  • ASME Journal of Biomechanical Engineering, Nov 2022, 2022.09.13.507860
  • [PDF, Link]
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  • Comparing acute IOP-induced lamina cribrosa deformations pre-mortem and post-mortem
  • J Wei, Y Hua, B Yang, B Wang, SE Schmitt, B Wang, KA Lucy, H Ishikawa, JS Schuman, MA Smith, G Wollstein, IA Sigal
  • Translational Vision Science & Technology, Oct 2022, 2022.09.18.508448
    • [
  • [PDF, Link]
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  • Comparing acute IOP-induced lamina cribrosa deformations pre-mortem and post-mortem
  • J Wei, Y Hua, B Yang, B Wang, SE Schmitt, B Wang, KA Lucy, H Ishikawa, JS Schuman, MA Smith, G Wollstein, IA Sigal
  • Translational Vision Science & Technology, Oct 2022, 2022.09.18.508448
  • [PDF, Link]
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  • Evidence of an Annexin A4 mediated plasma membrane repair response to biomechanical strain associated with glaucoma pathogenesis
  • N Vicic, X Guo, D Chan, JG Flanagan, IA Sigal, JM Sivak
  • Journal of Cellular Physiology, 2022 Sep;237(9):3687-3702, Epub July 21. doi: 10.1002/jcp.30834. PMID: 35862065.
  • [PDF, Link]
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  • Evidence of an Annexin A4 mediated plasma membrane repair response to biomechanical strain associated with glaucoma pathogenesis
  • N Vicic, X Guo, D Chan, JG Flanagan, IA Sigal, JM Sivak
  • Journal of Cellular Physiology, 2022 Sep;237(9):3687-3702, Epub July 21. doi: 10.1002/jcp.30834. PMID: 35862065.
  • [PDF, Link]
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  • Eye-specific 3D modeling of factors influencing oxygen concentration in the lamina cribrosa
  • Y Hua, Y Lu, J Walker, PY Lee, Q Tian, H McDonald, P Pallares, F Ji, BL Brazile, B Yang, AP Vorhees, IA Sigal
  • Experimental Eye Research, 2022;220:109105. July 2022. doi: 10.1016/j.exer.2022.109105. PMID: 35568202.
  • [PDF, Link, Video 1, Video 2]
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  • Eye-specific 3D modeling of factors influencing oxygen concentration in the lamina cribrosa
  • Y Hua, Y Lu, J Walker, PY Lee, Q Tian, H McDonald, P Pallares, F Ji, BL Brazile, B Yang, AP Vorhees, IA Sigal
  • Experimental Eye Research, 2022;220:109105. July 2022. doi: 10.1016/j.exer.2022.109105. PMID: 35568202.
  • [PDF, Link, Video 1, Video 2]
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  • A high-accuracy and high-efficiency digital volume correlation method to characterize in-vivo optic nerve head biomechanics from optical coherence tomography
  • F Zhong, B Wang, J Wei, Y Hua, B Wang, J Reynaud, B Fortune, IA Sigal
  • Acta Biomaterialia, 2022;143:72-86. April 2022, doi:10.1016/j.actbio.2022.02.021. PMID 35196556.
  • [PDF, Link]
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  • A high-accuracy and high-efficiency digital volume correlation method to characterize in-vivo optic nerve head biomechanics from optical coherence tomography
  • F Zhong, B Wang, J Wei, Y Hua, B Wang, J Reynaud, B Fortune, IA Sigal
  • Acta Biomaterialia, 2022;143:72-86. April 2022, doi:10.1016/j.actbio.2022.02.021. PMID 35196556.
  • [PDF, Link]
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  • A workflow for 3D reconstruction and quantification of the monkey optic nerve head vascular network
  • PY Lee, Y Hua, BL Brazile, B Yang, L Wang, IA Sigal
  • ASME Journal of Biomechanical Engineering, 2022;144(6):061006. June 2022, doi:10.1115/1.4054056
  • [PDF, Link]
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  • A workflow for 3D reconstruction and quantification of the monkey optic nerve head vascular network
  • PY Lee, Y Hua, BL Brazile, B Yang, L Wang, IA Sigal
  • ASME Journal of Biomechanical Engineering, 2022;144(6):061006. June 2022, doi:10.1115/1.4054056
  • [PDF, Link]
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  • Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy
  • PY Lee, B Yang, Y Hua, S Waxman, Z Ziyi, F Ji, IA Sigal
  • Experimental eye research, 217, 109867, April 2022.
  • [PDF, Link]
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  • Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy
  • PY Lee, B Yang, Y Hua, S Waxman, Z Ziyi, F Ji, IA Sigal
  • Experimental eye research, 217, 109867, April 2022.
  • [PDF, Link]
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  • Lamina cribrosa vessel and collagen beam networks are distinct
  • S Waxman ,BL Brazile, B Yang, PY Lee, Y Hua, AL Gogola, P Lam, AP Voorhees, III JF Rizzo, TC Jakobs, IA Sigal
  • Experimental eye research, 215, 108916, December 2021.
  • [PDF, Link]
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  • Lamina cribrosa vessel and collagen beam networks are distinct
  • S Waxman, BL Brazile, B Yang, PY Lee, Y Hua, AL Gogola, P Lam, AP Voorhees, III JF Rizzo, TC Jakobs, IA Sigal
  • Experimental eye research, 215, 108916, December 2021.
  • [PDF, Link]
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  • Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo
  • Z Zhu, S Waxman, B Wang, J Wallace, SE Schmitt, E Tyler-Kabara, H Ishikawa, JS Schuman, MA Smith, G Wollstein, IA Sigal
  • Experimental eye research, 213, 108809, December 2021.
  • [PDF, Link]
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  • Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo
  • Z Zhu, S Waxman, B Wang, J Wallace, SE Schmitt, E Tyler-Kabara, H Ishikawa, JS Schuman, MA Smith, G Wollstein, IA Sigal
  • Experimental eye research, 213, 108809, December 2021.
  • [PDF, Link]
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  • Instant polarized light microscopy for imaging collagen microarchitecture and dynamics
  • B Yang, PY Lee, Y Hua, B Brazile, S Waxman, F Ji, Z Zhu and IA Sigal
  • Journal of Biophotonics, 14(2), e202000326, February 2021.
  • [PDF, Link]
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  • Instant polarized light microscopy for imaging collagen microarchitecture and dynamics
  • B Yang, PY Lee, Y Hua, B Brazile, S Waxman, F Ji, Z Zhu and IA Sigal
  • Journal of Biophotonics, 14(2), e202000326, February 2021.
  • [PDF, Link]
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  • So-called lamina cribrosa defects may mitigate IOP-induced neural tissue insult
  • A*P Voorhees, *Y Hua, BL Brazile, BR Wang, S Waxman, JS Schuman and IA Sigal
  • Investigative Ophthalmology and Visual Science, 61(15), November 2020.
  • (* Authors contributed equally to this manuscript)
  • [PDF, Free to read Link]
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  • So-called lamina cribrosa defects may mitigate IOP-induced neural tissue insult
  • *AP Voorhees, *Y Hua, BL Brazile, B Wang, S Waxman, JS Schuman and IA Sigal
  • Investigative Ophthalmology and Visual Science, 61(15), November 2020.
  • (* Authors contributed equally to this manuscript)
  • [PDF, Free to read Link]
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  • Lamina cribrosa capillaries straighten as intraocular pressure increases
  • BL Brazile, B Yang, S Waxman, P Lam, AP Voorhees, Y Hua, RT Loewen, NA Loewen, JF Rizzo, T Jakobs and IA Sigal
  • Investigative Ophthalmology and Visual Science, 61(2), October 2020.
  • [PDF, Free to read Link]
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  • Lamina cribrosa capillaries straighten as intraocular pressure increases
  • BL Brazile, B Yang, S Waxman, P Lam, AP Voorhees, Y Hua, RT Loewen, NA Loewen, JF Rizzo, T Jakobs and IA Sigal
  • Investigative Ophthalmology and Visual Science, 61(2), October 2020.
  • [PDF, Free to read Link]
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  • Role of radially aligned scleral collagen fibers in optic nerve head biomechanics
  • Y Hua, AP Voorhees, NJ Jan, BR Wang, S Waxman, JS Schuman and IA Sigal
  • Experimental eye research, 199, 108188, October 2020.
  • [PDF, Link]
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  • Role of radially aligned scleral collagen fibers in optic nerve head biomechanics
  • Y Hua, AP Voorhees, NJ Jan, BR Wang, S Waxman, JS Schuman and IA Sigal
  • Experimental eye research, 199, 108188, October 2020.
  • [PDF, Link]
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  • Collagen fiber interweaving is central to sclera stiffness
  • BR Wang, Y Hua, BL Brazile, B Yang and IA Sigal
  • Acta Biomaterialia, 113, 429-437, September 2020.
  • [PDF, Link]
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  • Collagen fiber interweaving is central to sclera stiffness
  • BR Wang, Y Hua, BL Brazile, B Yang and IA Sigal
  • Acta Biomaterialia, 113, 429-437, September 2020.
  • [PDF, Link]
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  • Connective tissue remodeling in myopia and its potential role in increasing risk of glaucoma
  • R Grytz, H Yang, Y Hua, BC Samuels, IA Sigal
  • Current Opinion in Biomedical Engineering, 15, 40-50, September 2020.
  • [PDF, Link]
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  • Connective tissue remodeling in myopia and its potential role in increasing risk of glaucoma
  • R Grytz, H Yang, Y Hua, BC Samuels, IA Sigal
  • Current Opinion in Biomedical Engineering, 15, 40-50, September 2020.
  • [PDF, Link]
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  • Effect of iStent Trabecular Micro-Bypass device on outflow system morphology
  • N Hess, N Mesiwala, C Marando, RA Bilonick, LK Seibold, JS Schuman, G Wollstein, H Ishikawa, IA Sigal, I Conner, C Jonescu-Cuypers
  • Modeling and Artificial Intelligence in Ophthalmology, 2(4), 44-54, June 2020.
  • [PDF, Link]
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  • Effect of iStent Trabecular Micro-Bypass device on outflow system morphology
  • N Hess, N Mesiwala, C Marando, RA Bilonick, LK Seibold, JS Schuman, G Wollstein, H Ishikawa, IA Sigal, I Conner, C Jonescu-Cuypers
  • Modeling and Artificial Intelligence in Ophthalmology, 2(4), 44-54, June 2020.
  • [PDF, Link]
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  • Test-retest reproducibility of atomic force microscopy measurements of human trabecular meshwork stiffness
  • L Kagemann, J Candiello, G Wollstein, H Ishikawa, RA Bilonick, IA Sigal, C Jonescu-Cuypers, PN Kumta, JS Schuman
  • Modeling and Artificial Intelligence in Ophthalmology, 2(4), 34-43, June 2020.
  • [PDF, Link]
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  • Test-retest reproducibility of atomic force microscopy measurements of human trabecular meshwork stiffness
  • L Kagemann, J Candiello, G Wollstein, H Ishikawa, RA Bilonick, IA Sigal, C Jonescu-Cuypers, PN Kumta, JS Schuman
  • Modeling and Artificial Intelligence in Ophthalmology, 2(4), 34-43, June 2020.
  • [PDF, Link]
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  • Instant polarized light microscopy for real-time wide-field visualization of collagen architecture
  • PY Lee, B Yang, Y Hua, BL Brazile, FT Ji, ZY Zhu, GA Fryc, IA Sigal
  • Proceeding of SPIE, Label-free Biomedical Imaging and Sensing (LBIS) 2020, 112510Y, February 2020.
  • [PDF, Link]
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  • Instant polarized light microscopy for real-time wide-field visualization of collagen architecture
  • PY Lee, B Yang, Y Hua, BL Brazile, FT Ji, ZY Zhu, GA Fryc, IA Sigal
  • Proceeding of SPIE, Label-free Biomedical Imaging and Sensing (LBIS) 2020, 112510Y, February 2020.
  • [PDF, Link]
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  • A mesh-free approach to incorporate complex anisotropic and heterogeneous material properties into eye-specific finite element models
  • R Grytz, K Krishnan, R Whitley, V Libertiaux, IA Sigal, CA Girkin and JC Downs
  • Computer Methods in Applied Mechanics and Engineering, 358, 112654, January 2020.
  • [PDF, Link]
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  • A mesh-free approach to incorporate complex anisotropic and heterogeneous material properties into eye-specific finite element models
  • R Grytz, K Krishnan, R Whitley, V Libertiaux, IA Sigal, CA Girkin and JC Downs
  • Computer Methods in Applied Mechanics and Engineering, 358, 112654, January 2020.
  • [PDF, Link]
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  • Scleral structure and biomechanics
  • C Boote, IA Sigal, R Grytz, Y Hua, TD Nguyen and MJA Girard
  • Progress in Retinal and Eye Research, 74, 100773, January 2020.
  • [PDF, Link]
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  • Scleral structure and biomechanics
  • C Boote, IA Sigal, R Grytz, Y Hua, TD Nguyen and MJA Girard
  • Progress in Retinal and Eye Research, 74, 100773, January 2020.
  • [PDF, Link]
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  • Structured polarized light microscopy for collagen fiber structure and orientation quantification in thick ocular tissues
  • B Yang, BL Brazile, NJ Jan, Y Hua, J Wei and IA Sigal
  • Journal of Biomedical Optics, 23(10), 106001, October 2018.
  • [PDF, Link]
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  • Structured polarized light microscopy for collagen fiber structure and orientation quantification in thick ocular tissues
  • B Yang, BL Brazile, NJ Jan, Y Hua, J Wei and IA Sigal
  • Journal of Biomedical Optics, 23(10), 106001, October 2018.
  • [PDF, Link]
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  • Radial and circumferential collagen fibers are a feature of the peripapillary sclera of human, monkey, pig, cow, goat and sheep
  • A Gogola, NJ Jan, KL Lathrop and IA Sigal
  • Investigative Ophthalmology and Visual Science, 59(12), 4763-4774, October 2018.
  • [PDF, Free to read Link]
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  • Radial and circumferential collagen fibers are a feature of the peripapillary sclera of human, monkey, pig, cow, goat and sheep
  • A Gogola, NJ Jan, KL Lathrop and IA Sigal
  • Investigative Ophthalmology and Visual Science, 59(12), 4763-4774, October 2018.
  • [PDF, Free to read Link]
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  • Thin lamina cribrosa beams have different collagen microstructure than thick beams
  • *BL Brazile, *Y Hua, NJ Jan, J Wallace, A Gogola and IA Sigal
  • Investigative Ophthalmology and Visual Science, 59(11), 4653-4661, September 2018.
  • (* Authors contributed equally to this manuscript)
  • [PDF, Free to read Link]
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  • Thin lamina cribrosa beams have different collagen microstructure than thick beams
  • *BL Brazile, *Y Hua, NJ Jan, J Wallace, A Gogola and IA Sigal
  • Investigative Ophthalmology and Visual Science, 59(11), 4653-4661, September 2018.
  • (* Authors contributed equally to this manuscript)
  • [PDF, Free to read Link]
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  • Peripapillary sclera architecture revisited: A tangential fiber model and its biomechanical implications
  • AP Voorhees, NJ Jan, Y Hua, B Yang and IA Sigal
  • Acta Biomaterialia, 79, 113-122, August 2018.
  • [PDF, Link]
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  • Peripapillary sclera architecture revisited: A tangential fiber model and its biomechanical implications
  • AP Voorhees, NJ Jan, Y Hua, B Yang and IA Sigal
  • Acta Biomaterialia, 79, 113-122, August 2018.
  • [PDF, Link]
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  • Spatial patterns and age-related changes of the collagen crimp in the human cornea and sclera
  • A Gogola, NJ Jan, BL Brazile, P Lam, KL Lathrop, K Chan, IA Sigal
  • Investigative Ophthalmology and Visual Science, 59(7), 2987-2998, June 2018.
  • [PDF, Free to read Link]
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  • Spatial patterns and age-related changes of the collagen crimp in the human cornea and sclera
  • A Gogola, NJ Jan, BL Brazile, P Lam, KL Lathrop, K Chan, IA Sigal
  • Investigative Ophthalmology and Visual Science, 59(7), 2987-2998, June 2018.
  • [PDF, Free to read Link]
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  • Tortuous pore path through the glaucomatous lamina cribrosa
  • B Wang, KA Lucy, JS Schuman, IA Sigal, RA Bilonick, C Lu, J Liu, I Grulkowski, Z Nadler, H Ishikawa, L Kagemann, JG Fujimoto and G Wollstein
  • Scientific reports, 8(1), 7281, May 2018.
  • [PDF, Free to read link]
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  • Tortuous pore path through the glaucomatous lamina cribrosa
  • B Wang, KA Lucy, JS Schuman, IA Sigal, RA Bilonick, C Lu, J Liu, I Grulkowski, Z Nadler, H Ishikawa, L Kagemann, JG Fujimoto and G Wollstein
  • Scientific reports, 8(1), 7281, May 2018.
  • [PDF, Free to read link]
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  • Crimp around the globe: Patterns of collagen crimp across the corneoscleral shell
  • NJ Jan, BL Brazile, D Hu, G Grube, J Wallace, A Gogola and IA Sigal
  • Experimental eye research, 172, 159-170, April 2018.
  • [PDF, Link]
image
  • Crimp around the globe: Patterns of collagen crimp across the corneoscleral shell
  • NJ Jan, BL Brazile, D Hu, G Grube, J Wallace, A Gogola and IA Sigal
  • Experimental eye research, 172, 159-170, April 2018.
  • [PDF, Link]
image
  • Polarized light microscopy for 3D mapping of collagen fiber architecture in ocular tissues
  • B Yang, NJ Jan, B Brazile, A Voorhees, KL Lathrop and IA Sigal
  • Journal of Biophotonics, 11(8), e201700356, August 2018.
  • [PDF, Link]
image
  • Polarized light microscopy for 3D mapping of collagen fiber architecture in ocular tissues
  • B Yang, NJ Jan, B Brazile, A Voorhees, KL Lathrop and IA Sigal
  • Journal of Biophotonics, 11(8), e201700356, August 2018.
  • [PDF, Link]
image
  • Structured polarized light microscopy (SPLM) for mapping collagen fiber orientation of ocular tissues
  • B Yang, B Brazile, NJ Jan, AP Voorhees and IA Sigal
  • Proceeding of SPIE, Micromirror Device Based Systems and Applications X, 105460I, February 2018.
  • [PDF, Link]
image
  • Structured polarized light microscopy (SPLM) for mapping collagen fiber orientation of ocular tissues
  • B Yang, B Brazile, NJ Jan, AP Voorhees and IA Sigal
  • Proceeding of SPIE, Micromirror Device Based Systems and Applications X, 105460I, February 2018.
  • [PDF, Link]
image
  • Measuring in-vivo and in-situ ex-vivo the 3D deformation of the lamina cribrosa microstructure under elevated intraocular pressure
  • J Wei, B Yang, AP Voorhees, H Tran, B Brazile, B Wang, J Schuman, MA Smith, G Wollstein and IA Sigal
  • Proceeding of SPIE, Optical Elastography and Tissue Biomechanics V, 1049611, February 2018.
  • [PDF, Link]
image
  • Measuring in-vivo and in-situ ex-vivo the 3D deformation of the lamina cribrosa microstructure under elevated intraocular pressure
  • J Wei, B Yang, AP Voorhees, H Tran, B Brazile, B Wang, J Schuman, MA Smith, G Wollstein and IA Sigal
  • Proceeding of SPIE, Optical Elastography and Tissue Biomechanics V, 1049611, February 2018.
  • [PDF, Link]
image
  • Seeing the hidden lamina; Effects of exsanguination on the optic nerve head
  • H Tran, J Wallace, Z Zhu, KA Lucy, AP Voorhees, SE Schmitt, RA Bilonick, JS Schuman, MA Smith, G Wollstein, and IA Sigal
  • Investigative Ophthalmology and Visual Science, 59, 2564-2575, May 2018.
  • [PDF, Free to read Link]
image
  • Seeing the hidden lamina; Effects of exsanguination on the optic nerve head
  • H Tran, J Wallace, Z Zhu, KA Lucy, AP Voorhees, SE Schmitt, RA Bilonick, JS Schuman, MA Smith, G Wollstein, and IA Sigal
  • Investigative Ophthalmology and Visual Science, 59, 2564-2575, May 2018.
  • [PDF, Free to read Link]
image
  • Collagen fiber recruitment: a microstructural basis for the nonlinear response of the posterior pole of the eye to increases in intraocular pressure
  • NJ Jan and IA Sigal
  • Acta Biomaterialia, 72, 295-305, May 2018.
  • [PDF, Link]
image
  • Collagen fiber recruitment: a microstructural basis for the nonlinear response of the posterior pole of the eye to increases in intraocular pressure
  • NJ Jan and IA Sigal
  • Acta Biomaterialia, 72, 295-305, May 2018.
  • [PDF, Link]
image
  • Gaze evoked deformations in optic nerve head drusen: repetitive shearing as a potential factor in the visual and vascular complications
  • PA Sibony, J Wei and IA Sigal
  • Ophthalmology, 125(6), 929-937, June 2018.
  • [PDF, Link]
image
  • Gaze evoked deformations in optic nerve head drusen: repetitive shearing as a potential factor in the visual and vascular complications
  • PA Sibony, J Wei and IA Sigal
  • Ophthalmology, 125(6), 929-937, June 2018.
  • [PDF, Link]
image
  • Cerebrospinal Fluid Pressure; Revisiting Factors Influencing Optic Nerve Head Biomechanics
  • Y Hua, AP Voorhees and IA Sigal
  • Investigative Ophthalmology and Visual Science, 59(1), 154-165, January 2018.
  • [PDF, Free to read Link]
image
  • Cerebrospinal Fluid Pressure; Revisiting Factors Influencing Optic Nerve Head Biomechanics
  • Y Hua, AP Voorhees and IA Sigal
  • Investigative Ophthalmology and Visual Science, 59(1), 154-165, January 2018.
  • [PDF, Free to read Link]
image
  • In-Vivo Effects of Intraocular and Intracranial Pressures on the Lamina Cribrosa Microstructure
  • *B Wang, *H Tran, MA Smith, T Kostanyan, SE Schmitt, RA Bilonick, NJ Jan, L Kagemann, EC Tyler-Kabara, H Ishikawa, JS Schuman, IA Sigal and G Wollstein
  • PLoS ONE, 12(11), e0188302, November 2017.
  • (* Authors contributed equally to this manuscript)
  • [PDF, Link]
image
  • In-Vivo Effects of Intraocular and Intracranial Pressures on the Lamina Cribrosa Microstructure
  • *B Wang, *H Tran, MA Smith, T Kostanyan, SE Schmitt, RA Bilonick, NJ Jan, L Kagemann, EC Tyler-Kabara, H Ishikawa, JS Schuman, IA Sigal and G Wollstein
  • PLoS ONE, 12(11), e0188302, November 2017.
  • (* Authors contributed equally to this manuscript)
  • [PDF, Link]
image
  • Lamina Cribrosa Pore Shape and Size as Predictors of Neural Tissue Mechanical Insult
  • AP Voorhees, NJ Jan, ME Austin, JG Flanagan, JM Sivak, RA Bilonick and IA Sigal
  • Investigative Ophthalmology and Visual Science, 58(12), 5336-5346, October 2017.
  • [PDF, Free to read Link]
image
  • Lamina Cribrosa Pore Shape and Size as Predictors of Neural Tissue Mechanical Insult
  • AP Voorhees, NJ Jan, ME Austin, JG Flanagan, JM Sivak, RA Bilonick and IA Sigal
  • Investigative Ophthalmology and Visual Science, 58(12), 5336-5346, October 2017.
  • [PDF, Free to read Link]
image
  • Formalin Fixation and Cryosectioning Cause Only Minimal Changes in Shape or Size of Ocular Tissues
  • H Tran, NJ Jan, D Hu, A Voorhees, JS Schuman, MA Smith, G Wollstein and IA Sigal
  • Scientific Reports, 7(1), 12065, September 2017.
  • [PDF, Free to read link]
image
  • Formalin Fixation and Cryosectioning Cause Only Minimal Changes in Shape or Size of Ocular Tissues
  • H Tran, NJ Jan, D Hu, A Voorhees, JS Schuman, MA Smith, G Wollstein and IA Sigal
  • Scientific Reports, 7(1), 12065, September 2017.
  • [PDF, Free to read link]
image
  • Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes
  • B Wang, KA Lucy, JS Schuman, H Ishikawa, RA Bilonick, IA Sigal, L Kagemann, C Lu, JG Fujimoto and G Wollstein
  • Scientific Reports, 7(1), 9930, August 2017.
  • [PDF, Link]
image
  • Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes
  • B Wang, KA Lucy, JS Schuman, H Ishikawa, RA Bilonick, IA Sigal, L Kagemann, C Lu, JG Fujimoto and G Wollstein
  • Scientific Reports, 7(1), 9930, August 2017.
  • [PDF, Link]
image
  • Effects of collagen microstructure and material properties on the deformation of the neural tissues of the lamina cribrosa
  • AP Voorhees, NJ Jan and IA Sigal
  • Acta Biomaterialia, 58, 278-290, August 2017.
  • [PDF, Link]
image
  • Effects of collagen microstructure and material properties on the deformation of the neural tissues of the lamina cribrosa
  • AP Voorhees, NJ Jan and IA Sigal
  • Acta Biomaterialia, 58, 278-290, August 2017.
  • [PDF, Link]
image
  • Whole-globe biomechanics using high-field MRI
  • AP Voorhees, LC Ho, NJ Jan, H Tran, Y van der Merwe, K Chan and IA Sigal
  • Experimental Eye Research, 160, 85-95, July 2017.
  • [PDF, Link]
image
  • Whole-globe biomechanics using high-field MRI
  • AP Voorhees, LC Ho, NJ Jan, H Tran, Y van der Merwe, K Chan and IA Sigal
  • Experimental Eye Research, 160, 85-95, July 2017.
  • [PDF, Link]
image
  • Microstructural Crimp of the Lamina Cribrosa and Peripapillary Sclera Collagen Fibers
  • NJ Jan, C Gomez, S Moed, AP Voorhees, JS Schuman, RA Bilonick and IA Sigal
  • Investigative Ophthalmology and Visual Science, 58(9), 3378-3388, July 2017.
  • [PDF, Free to read link]
image
  • Microstructural Crimp of the Lamina Cribrosa and Peripapillary Sclera Collagen Fibers
  • NJ Jan, C Gomez, S Moed, AP Voorhees, JS Schuman, RA Bilonick and IA Sigal
  • Investigative Ophthalmology and Visual Science, 58(9), 3378-3388, July 2017.
  • [PDF, Free to read link]
image
  • Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility
  • KA Lucy, B Wang, JS Schuman, RA Bilonick, Y Ling, L Kagemann, IA Sigal, I Grulkowski, JJ Liu, JG Fujimoto, H Ishikawa and G Wollstein
  • Investigative Ophthalmology and Visual Science, 58(3), 1751-1757, March 2017.
  • [PDF, Free to read link]
image
  • Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility
  • KA Lucy, B Wang, JS Schuman, RA Bilonick, Y Ling, L Kagemann, IA Sigal, I Grulkowski, JJ Liu, JG Fujimoto, H Ishikawa and G Wollstein
  • Investigative Ophthalmology and Visual Science, 58(3), 1751-1757, March 2017.
  • [PDF, Free to read link]
image
  • An imaged-based inverse finite element method to determine in-vivo mechanical properties of human trabecular meshwork
  • AD Pant, L Kagemann, JS Schuman, IA Sigal and R Amini
  • Journal for Modeling in Ophthalmology, 1(3), 100-111, 2017.
  • [PDF, Free to read link]
image
  • An imaged-based inverse finite element method to determine in-vivo mechanical properties of human trabecular meshwork
  • AD Pant, L Kagemann, JS Schuman, IA Sigal and R Amini
  • Journal for Modeling in Ophthalmology, 1(3), 100-111, 2017.
  • [PDF, Free to read link]
image
  • Biomechanical aspects of axonal damage in glaucoma: A brief review
  • C Stowell, CF Burgoyne, ER Tamm, CR Ethier, JE Dowling, JC Downs, MH Ellisman, S Fisher, B Fortune, M Fruttiger, T Jakobs, G Lewis, CH Mitchell, J Morrison, SC Sharma, IA Sigal, M Sofroniew, L Wang, J Wiggs, S Wu and RH Masland
  • Experimental eye research, 157, 13-19, April 2017.
  • [PDF, Link]
image
  • Biomechanical aspects of axonal damage in glaucoma: A brief review
  • C Stowell, CF Burgoyne, ER Tamm, CR Ethier, JE Dowling, JC Downs, MH Ellisman, S Fisher, B Fortune, M Fruttiger, T Jakobs, G Lewis, CH Mitchell, J Morrison, SC Sharma, IA Sigal, M Sofroniew, L Wang, J Wiggs, S Wu and RH Masland
  • Experimental eye research, 157, 13-19, April 2017.
  • [PDF, Link]
image
  • Biological aspects of axonal damage in glaucoma: A brief review
  • ER Tamm, CR Ethier, CF Burgoyne, CR Ethier, ER Tamm, C Stowell, JE Dowling, JC Downs, MH Ellisman, S Fisher, B Fortune, M Fruttiger, T Jakobs, G Lewis, CH Mitchell, J Morrison, SC Sharma, IA Sigal, M Sofroniew, L Wang, J Wiggs, S Wu and RH Masland
  • Experimental eye research, 157, 5-12, April 2017.
  • [PDF, Link]
image
  • Biological aspects of axonal damage in glaucoma: A brief review
  • ER Tamm, CR Ethier, CF Burgoyne, CR Ethier, ER Tamm, C Stowell, JE Dowling, JC Downs, MH Ellisman, S Fisher, B Fortune, M Fruttiger, T Jakobs, G Lewis, CH Mitchell, J Morrison, SC Sharma, IA Sigal, M Sofroniew, L Wang, J Wiggs, S Wu and RH Masland
  • Experimental eye research, 157, 5-12, April 2017.
  • [PDF, Link]
image
  • Correlation between cerebral hemodynamic and perfusion pressure changes in non-human primates
  • A Ruesch, MA Smith, G Wollstein, IA Sigal, S Nelson and JM Kainerstorfer
  • Proceeding of SPIE, Optical Tomography and Spectroscopy of Tissue XII, 100591P, February 2017.
  • [PDF, Link]
image
  • Correlation between cerebral hemodynamic and perfusion pressure changes in non-human primates
  • A Ruesch, MA Smith, G Wollstein, IA Sigal, S Nelson and JM Kainerstorfer
  • Proceeding of SPIE, Optical Tomography and Spectroscopy of Tissue XII, 100591P, February 2017.
  • [PDF, Link]
image
  • Mapping in-vivo optic nerve head strains caused by intraocular and intracranial pressures
  • H Tran, J Grimm, B Wang, MA Smith, A Gogola, S Nelson, E Tyler-Kabara, J Schuman, G Wollstein and IA Sigal
  • Proceeding of SPIE, Optical Elastography and Tissue Biomechanics IV, 100670B, February 2017.
  • [PDF, Link]
image
  • Mapping in-vivo optic nerve head strains caused by intraocular and intracranial pressures
  • H Tran, J Grimm, B Wang, MA Smith, A Gogola, S Nelson, E Tyler-Kabara, J Schuman, G Wollstein and IA Sigal
  • Proceeding of SPIE, Optical Elastography and Tissue Biomechanics IV, 100670B, February 2017.
  • [PDF, Link]
image
  • Collagen architecture of the posterior pole; high-resolution, wide-field-of-view visualization and analysis using polarized light microscopy
  • NJ Jan, K Lathrop and IA Sigal
  • Investigative Ophthalmology and Visual Science, 58(2), 735744, February 2017.
  • [PDF, Free to read link]
image
  • Collagen architecture of the posterior pole; high-resolution, wide-field-of-view visualization and analysis using polarized light microscopy
  • NJ Jan, K Lathrop and IA Sigal
  • Investigative Ophthalmology and Visual Science, 58(2), 735744, February 2017.
  • [PDF, Free to read link]
image
  • Identifying the Palisades of Vogt in Human Ex-vivo Tissue
  • IA Sigal, J Steele, S Drexler and KL Lathrop
  • The Ocular Surface 14(4), 435-439, August 2016.
  • [PDF, Link]
image
  • Identifying the Palisades of Vogt in Human Ex-vivo Tissue
  • IA Sigal, J Steele, S Drexler and KL Lathrop
  • The Ocular Surface 14(4), 435-439, August 2016.
  • [PDF, Link]
image
  • Non-invasive MRI Assessments of Tissue Microstructures and Macromolecules in the Eye upon Biomechanical or Biochemical Modulation
  • LC Ho, IA Sigal, NJ Jan, X Yang, Y Van der Merwe, Y Yu, Y Chau, CK Leung, IP Conner, T Jin, EX Wu, SG Kim, G Wollstein, JS Schuman and KC Chan
  • Scientific Reports, 6(1), 1-14, August 2016.
  • [PDF, Free to read link]
image
  • Non-invasive MRI Assessments of Tissue Microstructures and Macromolecules in the Eye upon Biomechanical or Biochemical Modulation
  • LC Ho, IA Sigal, NJ Jan, X Yang, Y Van der Merwe, Y Yu, Y Chau, CK Leung, IP Conner, T Jin, EX Wu, SG Kim, G Wollstein, JS Schuman and KC Chan
  • Scientific Reports, 6(1), 1-14, August 2016.
  • [PDF, Free to read link]
image
  • Experimental glaucoma causes optic nerve head neural rim tissue compression: a potentially important mechanism of axon injury
  • B Fortune, J Reynaud, C Hardin, L Wang, IA Sigal and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 57(10), 4403-4411, August 2016.
  • [PDF, Free to read link]
image
  • Experimental glaucoma causes optic nerve head neural rim tissue compression: a potentially important mechanism of axon injury
  • B Fortune, J Reynaud, C Hardin, L Wang, IA Sigal and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 57(10), 4403-4411, August 2016.
  • [PDF, Free to read link]
image
  • What is a typical optic nerve head?
  • AP Voorhees, JL Grimm, RA Bilonick, L Kagemann, H Ishikawa, JS Schuman, G Wollstein, IA Sigal
  • Experimental Eye Research, 149, 40-47, June 2016.
  • [PDF, Link]
image
  • What is a typical optic nerve head?
  • AP Voorhees, JL Grimm, RA Bilonick, L Kagemann, H Ishikawa, JS Schuman, G Wollstein, IA Sigal
  • Experimental Eye Research, 149, 40-47, June 2016.
  • [PDF, Link]
image
  • Decreased lamina cribrosa beam thickness and pore diameter relative to distance from the central retinal vessel trunk
  • B Wang, KA Lucy, JS Schuman, IA Sigal, RA Bilonick, L Kagemann, T Kostanyan, C Lu, J Liu, I Grulkowski, JG Fujimoto, H Ishikawa, G Wollstein
  • Investigative Ophthalmology and Visual Science, 57(7), 3088-3092, June 2016.
  • [PDF, Free to read link]
image
  • Decreased lamina cribrosa beam thickness and pore diameter relative to distance from the central retinal vessel trunk
  • B Wang, KA Lucy, JS Schuman, IA Sigal, RA Bilonick, L Kagemann, T Kostanyan, C Lu, J Liu, I Grulkowski, JG Fujimoto, H Ishikawa, G Wollstein
  • Investigative Ophthalmology and Visual Science, 57(7), 3088-3092, June 2016.
  • [PDF, Free to read link]
image
  • Regionally Discrete Aqueous Humor Outflow Quantification Using Fluorescein Canalograms
  • RT Loewen, EN Brown, P Roy, JS Schuman, IA Sigal and NA Loewen
  • PLoS ONE, 11(3), e0151754, March 2016.
  • [PDF, Free to read link]
image
  • Regionally Discrete Aqueous Humor Outflow Quantification Using Fluorescein Canalograms
  • RT Loewen, EN Brown, P Roy, JS Schuman, IA Sigal and NA Loewen
  • PLoS ONE, 11(3), e0151754, March 2016.
  • [PDF, Free to read link]
image
  • A Problem of Proportions in OCT-based Morphometry and a Proposed Solution
  • IA Sigal, JS Schuman, H Ishikawa, L Kagemann and G Wollstein
  • Investigative Ophthalmology and Visual Science, 57(2), 484-485, Feburary 2016.
  • (Letter to the Editor)
  • [PDF, Free to read link]
image
  • A Problem of Proportions in OCT-based Morphometry and a Proposed Solution
  • IA Sigal, JS Schuman, H Ishikawa, L Kagemann and G Wollstein
  • Investigative Ophthalmology and Visual Science, 57(2), 484-485, Feburary 2016.
  • (Letter to the Editor)
  • [PDF, Free to read link]
image
  • MAPS – A Magic Angle Positioning System for Enhanced Imaging in High-Field Small-Bore MRI
  • A Squires, KC Chan, LC Ho, IA Sigal, NJ Jan and ZTH Tse
  • Journal of Medical Robotics Research 1(1), 1640004, April 2016.
  • [Link]
  • [PDF, Link]
image
  • MAPS – A Magic Angle Positioning System for Enhanced Imaging in High-Field Small-Bore MRI
  • A Squires, KC Chan, LC Ho, IA Sigal, NJ Jan and ZTH Tse
  • Journal of Medical Robotics Research 1(1), 1640004, April 2016.
  • [PDF, Link]
image
  • Use and Misuse of Laplace’s Law in Ophthalmology
  • CW Chung, MJA Girard, NJ Jan and IA Sigal
  • Investigative Ophthalmology and Visual Science, 57(1), 236-245, January 2016.
  • [PDF, Free to read link]
image
  • Use and Misuse of Laplace’s Law in Ophthalmology
  • CW Chung, MJA Girard, NJ Jan and IA Sigal
  • Investigative Ophthalmology and Visual Science, 57(1), 236-245, January 2016.
  • [PDF, Free to read link]
image
  • Polarization Microscopy for Characterizing Fiber Orientation of Ocular Tissues
  • NJ Jan, JL Grimm, H Tran, KL Lathrop, G Wollstein, RA Bilonick, H Ishikawa, L Kagemann, JS Schuman and IA Sigal
  • Biomedical Optics Express, 6(12), 4705-4718, December 2015.
  • [PDF, Link]
image
  • Polarization Microscopy for Characterizing Fiber Orientation of Ocular Tissues
  • NJ Jan, JL Grimm, H Tran, KL Lathrop, G Wollstein, RA Bilonick, H Ishikawa, L Kagemann, JS Schuman and IA Sigal
  • Biomedical Optics Express, 6(12), 4705-4718, December 2015.
  • [PDF, Link]
image
  • Translating Ocular Biomechanics into Clinical Practice: Current State and Future Prospects
  • MJA Girard, WJ Dupps, M Baskaran, G Scarcelli, SH Yun, HA Quigley, IA Sigal and NG Strouthidis
  • Current Eye Research, 40(1), 1-18, Jan 2015.
  • [PDF, Link]
image
  • Translating Ocular Biomechanics into Clinical Practice: Current State and Future Prospects
  • MJA Girard, WJ Dupps, M Baskaran, G Scarcelli, SH Yun, HA Quigley, IA Sigal and NG Strouthidis
  • Current Eye Research, 40(1), 1-18, Jan 2015.
  • [PDF, Link]
image
  • Glaucomatous cupping of the lamina cribrosa: A review of the evidence for active progressive remodeling as a mechanism
  • JC Downs, MD Roberts and IA Sigal
  • Experimental Eye Research, 93(2), 133-140, August 2011.
  • [PDF, Link]
image
  • Glaucomatous cupping of the lamina cribrosa: A review of the evidence for active progressive remodeling as a mechanism
  • JC Downs, MD Roberts and IA Sigal
  • Experimental Eye Research, 93(2), 133-140, August 2011
  • [PDF, Link]
image
  • In Vivo Evaluation of White Matter Inegrity and Anterograde Transport in Visual Systems After Excitoxic Retinal Injury with Multimodal MRI and OCT
  • LC Ho, B Wang, IP Conner, Y Van der Merwe, RA Bilonick, SG Kim, EX Wu, IA Sigal, G Wollstein, JS Schuman and KC Chan
  • Investigative Ophthalmology and Visual Science, 56(6), 3788-3800, June 2015.
  • [PDF, Free to read link]
image
  • In Vivo Evaluation of White Matter Inegrity and Anterograde Transport in Visual Systems After Excitoxic Retinal Injury with Multimodal MRI and OCT
  • LC Ho, B Wang, IP Conner, Y Van der Merwe, RA Bilonick, SG Kim, EX Wu, IA Sigal, G Wollstein, JS Schuman and KC Chan
  • Investigative Ophthalmology and Visual Science, 56(6), 3788-3800, June 2015.
  • [PDF, Free to read link]
image
  • Histogram Matching Extends Acceptable Signal Strength Range on Optical Coherence Tomography Images
  • CL Chen, H Ishikawa, G Wollstein, RA Bilonick, IA Sigal, L Kagemann and JS Schuman
  • Investigative Ophthalmology and Visual Science, 56(6), 3810-3819, June 2015.
  • [PDF, Free to read link]
image
  • Histogram Matching Extends Acceptable Signal Strength Range on Optical Coherence Tomography Images
  • CL Chen, H Ishikawa, G Wollstein, RA Bilonick, IA Sigal, L Kagemann and JS Schuman
  • Investigative Ophthalmology and Visual Science, 56(6), 3810-3819, June 2015.
  • [PDF, Free to read link]
image
  • Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
  • L Kagemann, B Wang, G Wollstein, H Ishikawa, B Mentley, IA Sigal, RA Bilonick and JS Schuman
  • Journal of Visualized Experiments, 20(100), e52611, June 2015.
  • [Link]
image
  • Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
  • L Kagemann, B Wang, G Wollstein, H Ishikawa, B Mentley, IA Sigal, RA Bilonick and JS Schuman
  • Journal of Visualized Experiments, 20(100), e52611, June 2015.
  • [Link]
image
  • Parameters for lithium treatment are critical in its enhancement of fracture-healing in rodents
  • J Bernick, Y Wang, IA Sigal, BA Alman, CM Whyne and D Nam
  • The Journal of bone and joint surgery. American volume, 96(23), 1990-1998, December 2014.
  • [PDF, Link]
image
  • Parameters for lithium treatment are critical in its enhancement of fracture-healing in rodents
  • J Bernick, Y Wang, IA Sigal, BA Alman, CM Whyne and D Nam
  • The Journal of bone and joint surgery. American volume, 96(23), 1990-1998, December 2014.
  • [PDF, Link]
image
  • Application of Elliptic Fourier Analysis to Describe the Lamina Cribrosa Shape with Age and Intraocular Pressure
  • PG Sanfilippo, JL Grimm, JG Flanagan, KL Lathrop and IA Sigal
  • Experimental Eye Research, 128, 1-7, November 2014.
  • [PDF, Link]
image
  • Application of Elliptic Fourier Analysis to Describe the Lamina Cribrosa Shape with Age and Intraocular Pressure
  • PG Sanfilippo, JL Grimm, JG Flanagan, KL Lathrop and IA Sigal
  • Experimental Eye Research, 128, 1-7, November 2014.
  • [PDF, Link]
image
  • In Vivo Three-Dimensional Characterization of the Healthy Human Lamina Cribrosa with Adaptive Optics Spectral-Domain Optical Coherence Tomography
  • Z Nadler, B Wang, JS Schuman, RD Ferguson, A Patel, DX Hammer, RA Bilonick, H Ishikawa, L Kagemann, IA Sigal and G Wollstein
  • Investigative Ophthalmology and Visual Science, 55(10), 6459-6466, October 2014.
  • [PDF, Free to read link]
image
  • In Vivo Three-Dimensional Characterization of the Healthy Human Lamina Cribrosa with Adaptive Optics Spectral-Domain Optical Coherence Tomography
  • Z Nadler, B Wang, JS Schuman, RD Ferguson, A Patel, DX Hammer, RA Bilonick, H Ishikawa, L Kagemann, IA Sigal and G Wollstein
  • Investigative Ophthalmology and Visual Science, 55(10), 6459-6466, October 2014.
  • [PDF, Free to read link]
image
  • Magic Angle-Enhanced MRI Of Fibrous Microstructures In Sclera And Cornea With And Without Intraocular Pressure Loading
  • *LC Ho, *IA Sigal, NJ Jan, A Squires, Z Tse, EX Wu, SG Kim, JS Schuman and KC Chan
  • Investigative Ophthalmology and Visual Science, 55(9), 5662-5672, September 2014.
  • (* Authors contributed equally to this manuscript)
  • [PDF, Free to read link]
image
  • Magic Angle-Enhanced MRI Of Fibrous Microstructures In Sclera And Cornea With And Without Intraocular Pressure Loading
  • *LC Ho, *IA Sigal, NJ Jan, A Squires, Z Tse, EX Wu, SG Kim, JS Schuman and KC Chan
  • Investigative Ophthalmology and Visual Science, 55(9), 5662-5672, September 2014.
  • (* Authors contributed equally to this manuscript)
  • [PDF, Free to read link]
image
  • Recent Advances in OCT Imaging of the Lamina Cribrosa
  • IA Sigal, B Wang, NG Strouthidis, T Akagi and MJA Girard
  • British Journal of Ophthalmology, 98(Suppl 2), ii34-ii39, July 2014.
  • [PDF, Free to read link]
image
  • Recent Advances in OCT Imaging of the Lamina Cribrosa
  • IA Sigal, B Wang, NG Strouthidis, T Akagi and MJA Girard
  • British Journal of Ophthalmology, 98(Suppl 2), ii34-ii39, June 2014.
  • [PDF, Free to read link]
image
  • Characterization of Schlemm’s Canal Cross-Sectional Area
  • L Kagemann, JE Nevins, NJ Jan, G Wollstein, H Ishikawa, J Kagemann, IA Sigal, Z Nadler, Y Ling and JS Schuman
  • British Journal of Ophthalmology, 98(Suppl 2), ii10-ii14, June 2014.
  • [PDF, Free to read link]
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  • Characterization of Schlemm’s Canal Cross-Sectional Area
  • L Kagemann, JE Nevins, NJ Jan, G Wollstein, H Ishikawa, J Kagemann, IA Sigal, Z Nadler, Y Ling and JS Schuman
  • British Journal of Ophthalmology, 98(Suppl 2), ii10-ii14, June 2014.
  • [PDF, Free to read link]
image
  • A Method to Estimate Biomechanics and Mechanical Properties of Optic Nerve Head Tissues From Parameters Measurable Using Optical Coherence Tomography
  • IA Sigal, JL Grimm, JS Schuman, L Kagemann, H Ishikawa and G Wollstein
  • IEEE Transactions on Medical Imaging, 33(6), 1381-1389, June 2014.
  • [PDF, Link]
  • Note: the applet associated with this paper is in the Software Page
image
  • A Method to Estimate Biomechanics and Mechanical Properties of Optic Nerve Head Tissues From Parameters Measurable Using Optical Coherence Tomography
  • IA Sigal, JL Grimm, JS Schuman, L Kagemann, H Ishikawa and G Wollstein
  • IEEE Transactions on Medical Imaging, 33(6), 1381-1389, June 2014.
  • [PDF, Link]
  • Note: the applet associated with this paper is in the Software Page
image
  • Reproducibility of In-Vivo OCT Measured Three-Dimensional Human Lamina Cribrosa Microarchitecture
  • B Wang, JE Nevins, Z Nadler, G Wollstein, H Ishikawa, RA Bilonick, L Kagemann, IA Sigal, I Grulkowski, JJ Liu, M Kraus, CD Lu, J Hornegger, JG Fujimoto and JS Schuman
  • PLoS ONE, 9(4), e95526, April 2014.
  • [PDF, Link]
image
  • Reproducibility of In-Vivo OCT Measured Three-Dimensional Human Lamina Cribrosa Microarchitecture
  • B Wang, JE Nevins, Z Nadler, G Wollstein, H Ishikawa, RA Bilonick, L Kagemann, IA Sigal, I Grulkowski, JJ Liu, M Kraus, CD Lu, J Hornegger, JG Fujimoto and JS Schuman
  • PLoS ONE, 9(4), e95526, April 2014.
  • [PDF, Link]
image
  • IOP Elevation Reduces Schlemm’s Canal Cross-sectional Area
  • L Kagemann, B Wang, G Wollstein, H Ishikawa, JE Nevins, Z Nadler, IA Sigal, RA Bilonick and JS Schuman
  • Investigative Ophthalmology and Visual Science, 55(3), 1805-1809, March 2014.
  • [PDF, Free to read link]
image
  • IOP Elevation Reduces Schlemm’s Canal Cross-sectional Area
  • L Kagemann, B Wang, G Wollstein, H Ishikawa, JE Nevins, Z Nadler, IA Sigal, RA Bilonick and JS Schuman
  • Investigative Ophthalmology and Visual Science, 55(3), 1805-1809, March 2014.
  • [PDF, Free to read link]
image
  • Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography
  • Z Nadler, B Wang, G Wollstein, JE Nevins, H Ishikawa, R Bilonick, L Kagemann, IA Sigal, RD Ferguson, A Patel, DX Hammer and JS Schuman
  • Biomedical Optics Express, 5(4), 1114-1123, April 2014.
  • [PDF, Link]
image
  • Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography
  • Z Nadler, B Wang, G Wollstein, JE Nevins, H Ishikawa, R Bilonick, L Kagemann, IA Sigal, RD Ferguson, A Patel, DX Hammer and JS Schuman
  • Biomedical Optics Express, 5(4), 1114-1123, April 2014.
  • [PDF, Link]
image
  • Gold Nanorods as a Contrast Agent for Doppler Optical Coherence Tomography
  • B Wang, L Kagemann, JS Schuman, H Ishikawa, RA Bilonick, Y Ling, IA Sigal, Z Nadler, A Francis, MG Sandrian and G Wollstein
  • PLoS One, 9(3), e90690, March 2014.
  • [PDF, Free to read link]
image
  • Gold Nanorods as a Contrast Agent for Doppler Optical Coherence Tomography
  • B Wang, L Kagemann, JS Schuman, H Ishikawa, RA Bilonick, Y Ling, IA Sigal, Z Nadler, A Francis, MG Sandrian and G Wollstein
  • PLoS One, 9(3), e90690, March 2014.
  • [PDF, Free to read link]
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image
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  • In-Vivo Lamina Cribrosa Microarchitecture in Healthy and Glaucomatous Eyes as Assessed by Optical Coherence Tomography
  • B Wang, JE Nevins, Z Nadler, G Wollstein, H Ishikawa, RA Bilonick, L Kagemann, IA Sigal, I Grulkowski, JJ Liu, M Kraus, CD Lu, J Hornegger, JG Fujimoto and JS Schuman
  • Investigative Ophthalmology and Visual Science, 54(13), 8270-8274, December 2013.
  • [PDF, Free to read link]
image
  • In-Vivo Lamina Cribrosa Microarchitecture in Healthy and Glaucomatous Eyes as Assessed by Optical Coherence Tomography
  • B Wang, JE Nevins, Z Nadler, G Wollstein, H Ishikawa, RA Bilonick, L Kagemann, IA Sigal, I Grulkowski, JJ Liu, M Kraus, CD Lu, J Hornegger, JG Fujimoto and JS Schuman
  • Investigative Ophthalmology and Visual Science, 54(13), 8270-8274, December 2013.
  • [PDF, Free to read link]
image
  • Automated Lamina Cribrosa Microstructural Segmentation in Optical Coherence Tomography Scans of Healthy and Glaucomatous Eyes
  • Z Nadler, B Wang, G Wollstein, J Nevins, H Ishikawa, L Kagemann, IA Sigal, RD Ferguson, DX Hammer, I Grulkowski, JJ Liu, MF Kraus, CD Lu, J Hornegger, JG Fujimoto and JS Schuman
  • Biomedical Optics Express, 4(11), 2596-2608, November 2013.
  • [PDF, Link]
image
  • Automated Lamina Cribrosa Microstructural Segmentation in Optical Coherence Tomography Scans of Healthy and Glaucomatous Eyes
  • Z Nadler, B Wang, G Wollstein, J Nevins, H Ishikawa, L Kagemann, IA Sigal, RD Ferguson, DX Hammer, I Grulkowski, JJ Liu, MF Kraus, CD Lu, J Hornegger, JG Fujimoto and JS Schuman
  • Biomedical Optics Express, 4(11), 2596-2608, November 2013.
  • [PDF, Link]
image
  • Signal Normalization Reduces Systematic Measurement Differences Between Spectral Domain Optical Coherence Tomography Devices
  • CL Chen, H Ishikawa, Y Ling, G Wollstein, RA Bilonick, J Xu, JG Fujimoto, IA Sigal, L Kagemann and JS Schuman
  • Investigative Ophthalmology and Visual Science, 54(12), 7317-7322, November 2013.
  • [PDF, Free to read link]
image
  • Signal Normalization Reduces Systematic Measurement Differences Between Spectral Domain Optical Coherence Tomography Devices
  • CL Chen, H Ishikawa, Y Ling, G Wollstein, RA Bilonick, J Xu, JG Fujimoto, IA Sigal, L Kagemann and JS Schuman
  • Investigative Ophthalmology and Visual Science, 54(12), 7317-7322, November 2013.
  • [PDF, Free to read link]
image
  • Individual A-Scan Signal Normalization Between Two Spectral Domain Optical Coherence Tomography Devices
  • CL Chen, H Ishikawa, G Wollstein, Y Ling, RA Bilonick, L Kagemann, IA Sigal and JS Schuman
  • Investigative Ophthalmology and Visual Science, 54(5),3463-3471, May 2013.
  • [PDF, Free to read link]
image
  • Individual A-Scan Signal Normalization Between Two Spectral Domain Optical Coherence Tomography Devices
  • CL Chen, H Ishikawa, G Wollstein, Y Ling, RA Bilonick, L Kagemann, IA Sigal and JS Schuman
  • Investigative Ophthalmology and Visual Science, 54(5), 3463-3471, May 2013.
  • [PDF, Free to read link]
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  • High Dynamic Range Imaging Concept-Based Signal Enhancement Method Reduced the Optical Coherence Tomography Measurement Variability
  • H Ishikawa, CL Chen, G Wollstein, JL Grimm, Y Ling, RA Bilonick, IA Sigal, L Kagemann and JS Schuman
  • Investigative Ophthalmology and Visual Science, 54(1), 836-841, January 2013.
  • [PDF, Free to read link]
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  • High Dynamic Range Imaging Concept-Based Signal Enhancement Method Reduced the Optical Coherence Tomography Measurement Variability
  • H Ishikawa, CL Chen, G Wollstein, JL Grimm, Y Ling, RA Bilonick, IA Sigal, L Kagemann and JS Schuman
  • Investigative Ophthalmology and Visual Science, 54(1):836-41, Jan 2013. PMID 23299477.
  • [PDF, Free to read link]
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  • Human Lamina Cribrosa Insertion and Age
  • IA Sigal, JG Flanagan, KL Lathrop, I Tertinegg and R Bilonick
  • Investigative Ophthalmology and Visual Science, 53(11), 6780-6789, October 2012.
  • [PDF, Free to read link]
image
  • Human Lamina Cribrosa Insertion and Age
  • IA Sigal, JG Flanagan, KL Lathrop, I Tertinegg and R Bilonick
  • Investigative Ophthalmology and Visual Science, 53(11):6780-9, Oct 2012. PMID 22956611.
  • [PDF, Free to read link]
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  • Morphometric Analysis of Aqueous Humor Outflow Structures with Spectral Domain Optical Coherence Tomography
  • AW Francis, L Kagemann, G Wollstein, H Ishikawa, S Folz, D Overby, IA Sigal, B Wang and JS Schuman
  • Investigative Ophthalmology and Visual Science, 53(9), 5198-207, September 2012.
  • [PDF, Free to read link]
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  • Morphometric Analysis of Aqueous Humor Outflow Structures with Spectral Domain Optical Coherence Tomography
  • AW Francis, L Kagemann, G Wollstein, H Ishikawa, S Folz, D Overby, IA Sigal, B Wang and JS Schuman
  • Invest Opthalmol Vis Sci, 53(9):5198-207, September 2012.
  • [PDF, Free to read link]
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  • Visualization of the Conventional Outflow Pathway in the Living Human Eye
  • L Kagemann, G Wollstein, H Ishikawa, Z Nadler, IA Sigal, LS Folio and JS Schuman
  • Ophthalmology, 119(8), 1563-1568, August 2012.
  • [PDF, Link]
image
  • Visualization of the Conventional Outflow Pathway in the Living Human Eye
  • L Kagemann, G Wollstein, H Ishikawa, Z Nadler, IA Sigal, LS Folio and JS Schuman
  • Ophthalmology, 119(8), 1563-1568, August 2012.
  • [PDF, Link]
image
  • A few good responses. Which mechanical effects of IOP on the ONH to study?
  • IA Sigal, JL Grimm
  • Investigative Ophthalmology and Visual Science, 53(7), 4270-4278, June 2012.
  • [PDF, Free to read link]
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  • A few good responses. Which mechanical effects of IOP on the ONH to study?
  • IA Sigal, JL Grimm
  • Investigative Ophthalmology and Visual Science, 53(7), 4270-4278, June 2012.
  • [PDF, Free to read link]
image
  • The Optic Nerve Head As A Robust Biomechanical System
  • IA Sigal,RA Bilonick, L Kagemann, G Wollstein, H Ishikawa, JS Schuman and JL Grimm
  • Investigative Ophthalmology and Visual Science, 53(6), 2658-2667, May 2012.
  • [PDF, Free to read link]
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  • The Optic Nerve Head As A Robust Biomechanical System
  • IA Sigal,RA Bilonick, L Kagemann, G Wollstein, H Ishikawa, JS Schuman and JL Grimm
  • Investigative Ophthalmology and Visual Science, 53(6), 2658-2667, May 2012.
  • [PDF, Free to read link]
image
  • Lamina Cribrosa Thickening in Early Glaucoma Predicted by a Microstructure Driven Growth and Remodeling Approach
  • R Grytz, IA Sigal, JW Ruberti, G Meschke and JC Downs
  • Mechanics of Materials, 44, 99-109, January 2012.
  • [PDF, Link]
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  • Lamina Cribrosa Thickening in Early Glaucoma Predicted by a Microstructure Driven Growth and Remodeling Approach
  • R Grytz, IA Sigal, JW Ruberti, G Meschke and JC Downs
  • Mechanics of Materials, 44, 99-109, January 2012.
  • [PDF, Link]
image
  • Effect of Acute Intraocular Pressure Elevation on the Monkey Optic Nerve Head as Detected by Spectral Domain Ocular Coherence Tomography
  • NG Strouthidis, B Fortune, H Yang, IA Sigal and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 52(12), 9431-9437, December 2011.
  • [PDF, Free to read link]
image
  • Effect of Acute Intraocular Pressure Elevation on the Monkey Optic Nerve Head as Detected by Spectral Domain Ocular Coherence Tomography
  • NG Strouthidis, B Fortune, H Yang, IA Sigal and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 52(12), 9431-9437, December 2011.
  • [PDF, Free to read link]
image
  • IOP-induced lamina cribrosa displacement and scleral canal expansion. Are they independent or related?
  • IA Sigal, H Yang, MD Roberts, JL Grimm, CF Burgoyne, S Demirel and JC Downs
  • Investigative Ophthalmology and Visual Science, 52(12), 9023-9032. December 2011.
  • [PDF, Free to read link]
image
  • IOP-induced lamina cribrosa displacement and scleral canal expansion. Are they independent or related?
  • IA Sigal, H Yang, MD Roberts, JL Grimm, CF Burgoyne, S Demirel and JC Downs
  • Investigative Ophthalmology and Visual Science, 52(12), 9023-9032. December 2011.
  • [PDF, Free to read link]
image
  • 3D Visualization of Aqueous Outflow Structures In the Living Human Eye
  • L Kagemann, G Wollstein, H Ishikawa, Z Nadler, IA Sigal, LS Folio, J Xu, H Gong and JS Schuman
  • Experimental eye research, 93(3), 308-315, September 2011.
  • Camras Special Issue
  • [PDF, Link]
image
  • 3D Visualization of Aqueous Outflow Structures In the Living Human Eye
  • L Kagemann, G Wollstein, H Ishikawa, Z Nadler, IA Sigal, LS Folio, J Xu, H Gong and JS Schumann
  • Experimental eye research, 93(3), 308-315, September 2011.
  • Camras Special Issue
  • [PDF, Link]
image
  • Posterior (outward) migration of the lamina cribrosa and early cupping in monkey experimental glaucoma
  • H Yang, G Williams, JC Downs, IA Sigal, MD Roberts, H Thompson and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 52(10), 7109-7921, September 2011.
  • [PDF, Free to read link]
image
  • Posterior (outward) migration of the lamina cribrosa and early cupping in monkey experimental glaucoma
  • H Yang, G Williams, JC Downs, IA Sigal, MD Roberts, H Thompson and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 52(10), 7109-7921, September 2011.
  • [PDF, Free to read link]
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  • An Applet to Estimate the IOP-Induced Stress and Strain Within the Optic Nerve Head
  • IA Sigal
  • Investigative Ophthalmology and Visual Science, 52(8), 5497-5506, July 2011.
  • [PDF, Free to read link]
  • Note: The applet associated with this paper is in the Software page.
image
  • An Applet to Estimate the IOP-Induced Stress and Strain Within the Optic Nerve Head
  • IA Sigal
  • Investigative Ophthalmology and Visual Science, 52(8), 5497-5506, July 2011.
  • [PDF, Free to read link]
  • Note: The applet associated with this paper is in the Software page.
image
  • Finite Element Modeling of the Human Sclera: Influence on Optic Nerve Head Biomechanics and Connections with Glaucoma
  • R Norman, JG Flanagan, IA Sigal, S Rausch, I Tertinegg and CR Ethier
  • Experimental Eye Research, 93(1), July 2011.
  • [PDF, Link]
image
  • Finite Element Modeling of the Human Sclera: Influence on Optic Nerve Head Biomechanics and Connections with Glaucoma
  • R Norman, JG Flanagan, IA Sigal, S Rausch, I Tertinegg and CR Ethier
  • Experimental Eye Research, 93(1), July 2011.
  • [PDF, Link]
image
  • IOP-Induced Lamina Cribrosa Displacement and Scleral Canal Expansion: an Analysis of Factor Interactions Using Parameterized Eye-Specific Models
  • IA Sigal, H Yang, MD Roberts, CF Burgoyne and JC Downs
  • Investigative Ophthalmology and Visual Science, 52(3), 1896-1907, March 2011.
  • [PDF, Free to read link]
image
  • IOP-Induced Lamina Cribrosa Displacement and Scleral Canal Expansion: an Analysis of Factor Interactions Using Parameterized Eye-Specific Models
  • IA Sigal, H Yang, MD Roberts, CF Burgoyne and JC Downs
  • Investigative Ophthalmology and Visual Science, 52(3), 1896-1907, March 2011.
  • [PDF, Free to read link]
image
  • Longitudinal Change Detected by Spectral Domain Optical Coherence Tomography in the Glaucomatous Optic Nerve Head and Peripapillary Retina
  • NG Strouthidis, B Fortune, H Yang, IA Sigal and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 52(3), 1206-1219, March 2011.
  • [PDF, Free to read link]
image
  • Longitudinal Change Detected by Spectral Domain Optical Coherence Tomography in the Glaucomatous Optic Nerve Head and Peripapillary Retina
  • NG Strouthidis, B Fortune, H Yang, IA Sigal and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 52(3), 1206-19, March 2011.
  • [PDF, Free to read link]
image
  • Deformation of the Early Glaucomatous Monkey Optic Nerve Head Connective Tissue Following Acute IOP Elevation Within 3-D Histomorphometric Reconstructions
  • H Yang, H Thompson, MD Roberts, IA Sigal, JC Downs and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 52(1), 345-363, January 2011.
  • [PDF, Free to read link]
image
  • Deformation of the Early Glaucomatous Monkey Optic Nerve Head Connective Tissue Following Acute IOP Elevation Within 3-D Histomorphometric Reconstructions
  • H Yang, H Thompson, MD Roberts, IA Sigal, JC Downs and CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 52(1), 345-363, January 2011.
  • [PDF, Free to read link]
image
  • Changes in the Biomechanical Response of the Optic Nerve Head in Early Experimental Glaucoma
  • MD Roberts, IA Sigal, Yi Liang, CF Burgoyne and JC Downs
  • Investigative Ophthalmology and Visual Science, 51(11):5675-5684. November 2010, PMID 20538997
  • [PDF, Free to read link]
image
  • Changes in the Biomechanical Response of the Optic Nerve Head in Early Experimental Glaucoma
  • MD Roberts, IA Sigal, Yi Liang, CF Burgoyne and JC Downs
  • Investigative Ophthalmology and Visual Science, 51(11):5675-5684. November 2010, PMID 20538997
  • [PDF, Free to read link]
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  • A Geometric Morphometric Assessment of the Optic Cup in Glaucoma
  • PG Sanfilippo, A Cardini, IA Sigal, J Ruddle, BE Chua, AW Hewitt, and DA Mackey
  • Experimental Eye Research, 91(3), 405-414, September 2010.
  • [PDF, Link]
image
  • A Geometric Morphometric Assessment of the Optic Cup in Glaucoma
  • PG Sanfilippo, A Cardini, IA Sigal, J Ruddle, BE Chua, AW Hewitt, and DA Mackey
  • Experimental Eye Research, 91(3), 405-414, September 2010.
  • [PDF, Link]
image
  • Biomechanical Changes of the Optic Disc
  • IA Sigal, MD Roberts, MJA Girard, CF Burgoyne and JC Down
  • Ocular Disease: Mechanisms and Management Eds: LA Levin and DM Albert, Saunders (Elsevier), Chapter 20, 704, March 2010.
  • ISBN 978-0-7020-2983-7
  • [PDF]
image
  • Biomechanical Changes of the Optic Disc
  • IA Sigal, MD Roberts, MJA Girard, CF Burgoyne and JC Down
  • Ocular Disease: Mechanisms and Management Eds: LA Levin and DM Albert, Saunders (Elsevier), Chapter 20, 704, March 2010.
  • ISBN 978-0-7020-2983-7
  • [PDF]
image
  • Dimensions of the Human Sclera: Thickness Measurement and Regional Changes with Axial Length
  • R Norman, JG Flanagan, S Rausch, IA Sigal, I Tertinegg, A Eilaghi, S Portnoy, J Sled and CR Ethier
  • Experimental Eye Research, 90(2), 277-284, Feburary 2010.
  • [PDF, Link]
image
  • Dimensions of the Human Sclera: Thickness Measurement and Regional Changes with Axial Length
  • R Norman, JG Flanagan, S Rausch, IA Sigal, I Tertinegg, A Eilaghi, S Portnoy, J Sled and CR Ethier
  • Experimental Eye Research, 90(2), 277-284, Feburary 2010.
  • [PDF, Link]
image
  • 3D morphometry of the Human Optic Nerve Head
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Experimental Eye Research, 90(1), 70-80, January 2010.
  • [PDF, Link]
image
  • 3D morphometry of the Human Optic Nerve Head
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Experimental Eye Research, 90(1), 70-80, January 2010.
  • [PDF, Link]
image
  • Mesh Morphing and Response Surface Analysis: Quantifying Sensitivity of Vertebral Mechanical Behaviour
  • IA Sigal and CM Whyne
  • Annals of Biomedical Engineering, 38(1), 41-56, January 2010.
  • [PDF, Link]
image
  • Mesh Morphing and Response Surface Analysis: Quantifying Sensitivity of Vertebral Mechanical Behaviour
  • IA Sigal and CM Whyne
  • Annals of Biomedical Engineering, 38(1), 41-56, January 2010.
  • [PDF, Link]
image
  • Morphing Methods to Parameterize Specimen-Specific Finite Element Model Geometries
  • IA Sigal, H Yang, MD Roberts and JC Downs
  • Journal of Biomechanics, 43(2), 254-262, Jan 2010.
  • [PDF, Link]
image
  • Morphing Methods to Parameterize Specimen-Specific Finite Element Model Geometries
  • IA Sigal, H Yang, MD Roberts and JC Downs
  • Journal of Biomechanics, 43(2), 254-262, Jan 2010.
  • [PDF, Link]
image
  • Correlation Between Local Stress and Strain and Lamina Cribrosa Connective Tissue Volume Fraction in Normal Monkey Eyes
  • MD Roberts, Y Liang, IA Sigal, J Grimm, J Reynaud, A Bellezza, CF Burgoyne and JC Downs
  • Investigative Ophthalmology and Visual Science, 51(1), 295-307, January 2010.
  • [PDF, Free to read link]
image
  • Correlation Between Local Stress and Strain and Lamina Cribrosa Connective Tissue Volume Fraction in Normal Monkey Eyes
  • MD Roberts, Y Liang, IA Sigal, J Grimm, J Reynaud, A Bellezza, CF Burgoyne and JC Downs
  • Investigative Ophthalmology and Visual Science, 51(1), 295-307, January 2010.
  • [PDF, Free to read link]
image
  • Deformation of the Normal Monkey Optic Nerve Head Connective Tissues Following Acute IOP Elevation Within 3-D Histomorphometric Reconstructions
  • H Yang, JC Downs, IA Sigal, M Roberts, H Thompson, CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 50(12), 5785-5789. December 2009.
  • [PDF, Free to read link]
image
  • Deformation of the Normal Monkey Optic Nerve Head Connective Tissues Following Acute IOP Elevation Within 3-D Histomorphometric Reconstructions
  • H Yang, JC Downs, IA Sigal, M Roberts, H Thompson, CF Burgoyne
  • Investigative Ophthalmology and Visual Science, 50(12), 5785-5789. December 2009.
  • [PDF, Free to read link]
image
  • Interactions Between Geometry and Mechanical Properties on the Optic Nerve Head
  • IA Sigal
  • Investigative Ophthalmology and Visual Science, 50(6), 2785-2795, June 2009.
  • [PDF, Free to read link]
image
  • Interactions Between Geometry and Mechanical Properties on the Optic Nerve Head
  • IA Sigal
  • Investigative Ophthalmology and Visual Science, 50(6), 2785-2795, June 2009.
  • [PDF, Free to read link]
image
  • Biomechanics of the Optic Nerve Head
  • IA Sigal, CR Ethier
  • Experimental Eye Research, 88(4), 799-807, April 2009.
  • [PDF, Link]
image
  • Biomechanics of the Optic Nerve Head
  • IA Sigal, CR Ethier
  • Experimental Eye Research, 88(4), 799-807, April 2009.
  • [PDF, Link]
image
  • Modeling Individual-Specific Human Optic Nerve Head Biomechanics Part II: Influence of Material Properties
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Biomechanics and Modeling in Mechanobiology, 8(2), 99-109, April 2009.
  • [PDF, Link]
image
  • Modeling Individual-Specific Human Optic Nerve Head Biomechanics Part II: Influence of Material Properties
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Biomechanics and Modeling in Mechanobiology, 8(2), 99-109, April 2009.
  • [PDF, Link]
image
  • Modeling Individual-Specific Human Optic Nerve Head Biomechanics Part I: IOP-Induced Deformations and Influence of Geometry
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Biomechanics and Modeling in Mechanobiology, 8(2), 85-98, April 2009.
  • [PDF, Link]
image
  • Modeling Individual-Specific Human Optic Nerve Head Biomechanics Part I: IOP-Induced Deformations and Influence of Geometry
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Biomech Model Mechanobiol, 8(2), 85-98, Apr 2009.
  • [PDF, Link]
image
  • Mesh-Morphing Algorithms for Specimen-Specific Finite Element Modeling
  • IA Sigal, MR Hardisty and CM Whyne
  • Journal of Biomechanics, 41(7), 1381-1389, April 2008.
  • [PDF, Link]
image
  • Mesh-Morphing Algorithms for Specimen-Specific Finite Element Modeling
  • IA Sigal, MR Hardisty and CM Whyne
  • Journal of Biomechanics, 41(7), 1381-1389, April 2008.
  • [PDF, Link]
image
  • Predicted Extension, Compression and Shearing of Optic Nerve Head Tissues
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Experimental Eye Research, 85(3), 312-322, September 2007.
  • [PDF, Link]
image
  • Predicted Extension, Compression and Shearing of Optic Nerve Head Tissues
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Experimental Eye Research, 85(3), 312-322, September 2007.
  • [PDF, Link]
image
  • Factors Influencing Human Optic Nerve Head Biomechanics
  • IA Sigal, JG Flanagan and CR Ethier
  • Investigative Ophthalmology and Visual Science, 46(11), 4189-4199, November 2005.
  • [PDF, Free to read link]
image
  • Factors Influencing Human Optic Nerve Head Biomechanics
  • IA Sigal, JG Flanagan and CR Ethier
  • Investigative Ophthalmology and Visual Science, 46(11), 4189-4199, November 2005.
  • [PDF, Free to read link]
image
  • Reconstruction of Human Optic Nerve Heads for Finite Element Modeling
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Technology and Health Care: Official Journal of the European Society for Engineering and Medicine, 13(4), 313-329, August 2005.
  • [PDF, Link]
image
  • Reconstruction of Human Optic Nerve Heads for Finite Element Modeling
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Technology and Health Care: Official Journal of the European Society for Engineering and Medicine, 13(4), 313-329, August 2005.
  • [PDF, Link]
image
  • Finite Element Modeling of Optic Nerve Head Biomechanics
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Investigative Ophthalmology and Visual Science, 45(12), 4378-4387, December 2004.
  • [PDF, Free to read link]
image
  • Finite Element Modeling of Optic Nerve Head Biomechanics
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Investigative Ophthalmology and Visual Science, 45(12), 4378-4387, December 2004.
  • [PDF, Free to read link]
image
  • Investigation Of The Biomechanical Environment Within The Optic Nerve Head By Finite Element Modelling
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Computational Fluid and Solid Mechanics, 2nd MIT Conference on, Boston, June 17-20, 2003, K.J. Bathe (ed.), pp. 1810-1813, Elsevier (ISBN: 0-08-044046-0), 2003.
  • [PDF, Link]
image
  • Investigation Of The Biomechanical Environment Within The Optic Nerve Head By Finite Element Modelling
  • IA Sigal, JG Flanagan, I Tertinegg and CR Ethier
  • Computational Fluid and Solid Mechanics, 2nd MIT Conference on, Boston, June 17-20, 2003, K.J. Bathe (ed.), pp. 1810-1813, Elsevier (ISBN: 0-08-044046-0), 2003.
  • [PDF, Link]
image
  • Chirality in Bare and Passivated Gold Nanoclusters
  • IL Garzón, JA Reyes-Nava, JI Rodríguez-Hernández, I Sigal, MR Beltrán and K Michaelian
  • Physical Review B, 66(7), 073403, August 2002.
  • [PDF, Link]
image
  • Chirality in Bare and Passivated Gold Nanoclusters
  • IL Garzón, JA Reyes-Nava, JI Rodríguez-Hernández, I Sigal, MR Beltrán and K Michaelian
  • Physical Review B, 66(7), 073403, August 2002.
  • [PDF, Link]