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Laboratory of
Ocular Biomechanics

University of Pittsburgh

Latest News

June/2018: Podium presentation by Jason Hua

  • Vision Research Day, UPMC Department of Ophthalmology, Pittsburgh, PA, June 08, 2018.

May/2018: Congratulations Junchao Wei!

  • His work on "Measuring in-vivo and in-situ ex-vivo the 3D deformation of the lamina cribrosa microstructure under elevated intraocular pressure" received a Best Poster Presentations award at the 2018 Postdoctoral Data & Dine Symposium in Pittsburgh.

May/2018: New paper accepted

  • "Spatial patterns and age-related changes of the collagen crimp in the human cornea and sclera" by IOVS.

  • In collaboration with Kevin Chan at NYU.

May/2018: Two podium and one poster presentation:

  • Meeting of the Association for Research in Vision and Ophthalmology, Honolulu, HI, April 28 - May 3, 2018.

May/2018: Podium presentation:

  • ARVO Imaging meeting, Honolulu, HI, April 27, 2018.

April/2018: New paper accepted

April/2018: New paper accepted

April/2018: New paper accepted

March/2018: New paper accepted

  • "Seeing the hidden lamina; Effects of exsanguination on the optic nerve head" by IOVS.

  • In collaboration with the Matt smith at Pitt and Gadi Wollstein at NYU

March/2018: New paper accepted

Active projects
Click images for more info.

Why biomechanics of the eye?

In our daily lives we rarely think of the eye as a biomechanical structure. The eye, however, is a remarkably complex structure with biomechanics involved in many of its functions. For our eyes to be able to track moving objects, for example, requires a delicate balance of the forces exerted by several muscles. Forces are also responsible for deforming the lens and allow focusing. A slight imbalance between the forces and tissue properties may be enough to alter or even preclude vision. These effects may take place quickly or over long periods, even years. Understanding ocular biomechanics is therefore important for preventing and treating vision loss.

 

Eye diagram

Schematic cross-section through a human eye. Light enters the eye through the cornea, passes through the pupil, lens and vitreous humour and strikes the retina, where it is absorbed. Retinal nerve fibers transmit visual information to the brain. These fibers converge at the optic nerve head region, exit the eye through the scleral canal, and form the optic nerve. The lamina cribrosa is a porous structure spanning the scleral canal. The vitreous chamber is filled with the vitreous humor, which exerts a pressure, the intraocular pressure, on the surface of the retina. [Sigal et al. Biomech Model Mechanobiol, 8(2):85-98, Apr 2009] (adapted from an illustration from NIH)

 

Goals

The objective of the Laboratory of Ocular Biomechanics is to study the eye as a biomechanical structure. More specifically our work is aimed at identifying the causes of glaucoma, with the ultimate intention of finding a way to prevent vision loss.